September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
AMD Drusenoid deposits “L”,Lipid type and “P”,Protein-cellular type, characterization,evolution,structural analysis with Multimodal Imaging and Morphology-Structural software
Author Affiliations & Notes
  • Bruno Lay
    Research and Development, ADCIS, Saint Contest, France
  • CORINNE GONZALEZ
    FUTUROPHTA, TOULOUSE, France
  • Footnotes
    Commercial Relationships   Bruno Lay, ADCIS (P); CORINNE GONZALEZ, ADCIS (P)
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 43. doi:
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      Bruno Lay, CORINNE GONZALEZ; AMD Drusenoid deposits “L”,Lipid type and “P”,Protein-cellular type, characterization,evolution,structural analysis with Multimodal Imaging and Morphology-Structural software. Invest. Ophthalmol. Vis. Sci. 2016;57(12):43.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To study AMD drusenoid deposits “L”and “P”,with multimodal imaging and morphology-structural software and see all the input of this technique and software on drusenoid deposits knowledge and etiopathogeny

Methods : 124 eyes of 74 patients,23 men,51 women,with AMD drusenoid deposits “L”,Lipid Type (soft Drusen,Drusenoid PED “L”)and “P”,Protein-cellular type (Pseudovitellifom AMD,Cuticular drusen,Subretinal drusenoid deposits(SDD),Drusenoid PED,”P”). Deposits were evaluated by Autofluorescence,IR imaging,OCT,notably OCT en Face(Spectralis HRA-OCT, spectral domainOCT), and Morphology-Structural software (M-S software). ETDRS visual acuity(VA),complete ophthalmic examination with Fundus exam were added. Size,characteristics,number,topography of the “L”and “P” deposits,their environment above and below(particularly IS-OS,plexiform layer,choriocapillaris structure and thickness)were evaluated,each element was studied,compared cut to cut,layer to layer and time to time. M-S software let analyze drusenoid deposit volume and contours,let a 3D deposit reconstruction,display in 3D space,let volume,density(grey levels of deposits),structure (structural measures, texture parameters),composition (density calculation) evaluation and characterization of those “L” and “P” type deposits

Results : AMD Drusenoid Deposits:“L” are larger,roughly uniform,dome-shaped,dark grey,translucent,optical empty, equal and the same in all cross-section,as lipid pearl drops,fatty,mounds of deposit under the RPE, abnormal Pigment epithelium above,but layer quite preserved, evolution to atrophy; “P”are dense ,white,heterogeneous PED,below Pigment Epithelium,granular, as Protein,membranous,cellular component, as Basal Laminar Deposit, different in all cross-sections,abnormal Pigment epithelium above,heavily unstructured,layer interrupted, cells disappeared, irregular IS/OS facing, evolution to neovascularization. M-S software allows: lipid composition confirmation for “L”type,selective lipid characterization,to better differentiate lipid and more components; protein composition confirmation for “P”type to better differentiate various protein components and more

Conclusions : Multimodal Imaging, Morphology-Structural Software contribute to and improve AMD Drusenoid deposits “L”, “P”, study and knowledge and so AMD etiopathogeny understanding

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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