September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Imaging of diabetic hard exudates : a comparison of retinal photographs, optical coherence tomography and adaptive optics
Author Affiliations & Notes
  • Christophe HENRIOT
    Departement of Ophthalmology, Besançon University Hospital, Besançon, France
  • Mathieu Flores
    Departement of Ophthalmology, Besançon University Hospital, Besançon, France
  • Guillaume Debellemanière
    Departement of Ophthalmology, Besançon University Hospital, Besançon, France
  • Bernard Y Delbosc
    Departement of Ophthalmology, Besançon University Hospital, Besançon, France
  • Maher Saleh
    Departement of Ophthalmology, Besançon University Hospital, Besançon, France
  • Footnotes
    Commercial Relationships   Christophe HENRIOT, None; Mathieu Flores, None; Guillaume Debellemanière, None; Bernard Delbosc, None; Maher Saleh, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 77. doi:
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      Christophe HENRIOT, Mathieu Flores, Guillaume Debellemanière, Bernard Y Delbosc, Maher Saleh; Imaging of diabetic hard exudates : a comparison of retinal photographs, optical coherence tomography and adaptive optics. Invest. Ophthalmol. Vis. Sci. 2016;57(12):77.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare the ability of color retinal photographs, spectral domain optical coherence tomography and adaptive optics in detecting hard exudates (HE) with decreasing size (HE, foci and micro foci) in patients presenting diabetic retinopathy.

Methods : Patients with diabetic retinopathy were studied. A multimodal imaging of an area of clinically visible exudates was conducted: a 45-degree retinography (Nonmyd 7 Retinal Camera, Kowa Company Limited, Nagoya,Japan), together with a spectral domain OCT with en-face reconstruction (Spectralis, Heidelberg Engineering, Heidelberg, Germany) and an adaptive optics imaging (RTX1, Imagine Eye, Orsay, France) were performed. Hard exudates (>50μm), foci (30-50μm) and microfocis (<30μm) were counted and were measured, in a blind manner by two examiners. The Kendall rank correlation coefficient was calculated as a measure of reliability between the pairs of imaging modalities.

Results : Fourteen eyes of 11 diabetic patients were studied. Hard exudates from 29 regions of interest were studied.Mean central macular thickness was 370um. The intermodality agreement for hard exudates count was good (Kendall Tau > 0.6, p<0.0001). For smaller exudates, there was a significant discrepancy between the different imaging modalities. Adaptive optics, and in less proportion OCT, showed that hard exudates were made of the aggregation of round deposits corresponding to focis. They also imaged deposits of a few microns not visible on photographs, that shared some characteristics with focis.

Conclusions : Intermodality agreement was relatively good for larger exudates. However, when it comes to study smaller structures, adaptive optics has shown to be superior. This imaging technique was the only one to accurately show exudates never described before, smaller in size than foci, we labeled micro foci.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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