September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Differential changes in intraocular pressure and corneal manifestations in individuals with viral endothelitis after keratoplasty
Author Affiliations & Notes
  • Yukiko Morita
    Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Japan
  • Naoyuki Morishige
    Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Japan
  • Naoyuki Yamada
    Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Japan
  • Koh-hei Sonoda
    Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Ophthalmology, Kyusyu University Graduate School of Medical Science, Fukuoka, Japan
  • Footnotes
    Commercial Relationships   Yukiko Morita, None; Naoyuki Morishige, None; Naoyuki Yamada, None; Koh-hei Sonoda, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 322. doi:
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    • Get Citation

      Yukiko Morita, Naoyuki Morishige, Naoyuki Yamada, Koh-hei Sonoda; Differential changes in intraocular pressure and corneal manifestations in individuals with viral endothelitis after keratoplasty. Invest. Ophthalmol. Vis. Sci. 2016;57(12):322.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the clinical characteristics of viral endothelitis after keratoplasty, we evaluated clinical parameters in individuals with anterior chamber inflammation after keratoplasty classified according to the absence or presence of DNA from various viruses in aqueous humor.

Methods : A total of 29 eyes of 27 subjects with anterior chamber inflammation after keratoplasty was enrolled in the study. The subjects were classified into the herpes simplex virus (HSV) group (7 patients, 8 eyes), cytomegalovirus (CMV) group (6 patients, 6 eyes), varicella zoster virus (VZV) group (2 patients, 2 eyes), and nonviral group (12 patients, 13 eyes). on the basis of the detection of the corresponding viral DNA in aqueous humor. The duration from the time of keratoplasty to the onset of inflammation, intraocular pressure (IOP), and corneal manifestations of inflammation were retrospectively reviewed.

Results : Sixteen of the 29 eyes developed anterior chamber inflammation within 2 years after keratoplasty. IOP during the active phase of inflammation was significantly increased in the HSV and CMV groups compared with pre-inflammation values. The increased IOP was significantly ameliorated in association with eradication of viral infection in these two groups. Linear-type keratoprecipitates were frequently detected in all groups with the exception of the VZV group. Corneal edema was apparent in the HSV and nonviral groups but not in the CMV and VZV groups.

Conclusions : Changes in IOP and corneal manifestations may provide a basis for the differentiation of causative pathogens in individuals with anterior chamber inflammation after keratoplasty, and they may thus allow initiation of appropriate treatment before viral DNA is identified.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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