September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Baseline structural parameters measured with optical coherence tomography predict functional progression in open-angle glaucoma patients after five years
Author Affiliations & Notes
  • Nicholas Moore
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Amelia Huang
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Colin Ridenour
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Ingrida Januleviciene
    Ophthalmology, Lithuanian Univ of Health Sciences, Kaunas, Lithuania
  • Lina Siaudvytyte
    Ophthalmology, Lithuanian Univ of Health Sciences, Kaunas, Lithuania
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Thomas A Ciulla
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Nicholas Moore, None; Alon Harris, AdOM (I), AdOM (C), Biolight (C), Isama Therapeutics (C), Nano Retina (C), Ono (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Brent Siesky, None; Amelia Huang, None; Colin Ridenour, None; Ingrida Januleviciene, Alcon (R), Allergan (R), Santen (R), Vittamed (S); Lina Siaudvytyte, None; George Eckert, None; Alice Chandra Verticchio Vercellin, None; Thomas Ciulla, None
  • Footnotes
    Support  Research to Prevent Blindness NY, NY
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 350. doi:
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      Nicholas Moore, Alon Harris, Brent A Siesky, Amelia Huang, Colin Ridenour, Ingrida Januleviciene, Lina Siaudvytyte, George Eckert, Alice Chandra Verticchio Vercellin, Thomas A Ciulla; Baseline structural parameters measured with optical coherence tomography predict functional progression in open-angle glaucoma patients after five years. Invest. Ophthalmol. Vis. Sci. 2016;57(12):350.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine baseline structural parameters and functional progression in open-angle glaucoma (OAG) patients over a five-year period

Methods : 111 OAG patients (mean age 65 ± 10.9 years; 43 male, 68 female) were assessed for optic nerve head morphology and retinal nerve fiber layer (RNFL) thickness by optical coherence tomography every six months for five years. Visual function was evaluated using Humphrey 24-2 visual fields. Functional progression was defined as two consecutive visits with mean deviation decrease ≥2 compared to baseline and/or Advanced Glaucoma Intervention Study score increase ≥2 compared to baseline. Mixed-model ANCOVA was used to test for statistically significant changes from baseline to five-year follow-up. Time to functional progression was analyzed using Cox proportional hazards survival analysis.

Results : Baseline disc area 2.27 (95% CI: 2.14, 2.40) increased at five years to 2.62 (2.47, 2.77), mean change 0.35 (0.25, 0.44; p<0.001). Baseline cup area 1.18 (1.02, 1.35) increased to 1.51 (1.32, 1.70), mean change 0.33 (0.23, 0.43; p<0.001). Baseline average RNFL thickness 74.9 (70.1, 79.7) decreased to 72.8 (67.6, 78.1), mean change -2.1 (-5.1, 0.9; p=0.174). A higher baseline disc area (p=0.008), higher baseline cup area (p=0.003), and lower baseline RNFL temporal thickness (p=0.003) were associated with shorter time to functional progression.

Conclusions : In our study of OAG patients, a larger disc area, larger cup area, and smaller temporal RNFL thickness measured at baseline were associated with a shorter time to functional vision loss after five years.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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