September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Functional and structural glaucoma progression after five years in patients with lowered intraocular pressure
Author Affiliations & Notes
  • Rachel Frantz
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Nicholas Moore
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Tyler Joseph Knight
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Betul Kaskan
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Darrell WuDunn
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Rachel Frantz, None; Alon Harris, AdOM (I), AdOM (C), Biolight (C), Isama therapeutics (C), Nano Retina (C), Ono (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Alice Chandra Verticchio Vercellin, None; Nicholas Moore, None; Tyler Knight, None; Betul Kaskan, None; George Eckert, None; Darrell WuDunn, Aerie Pharmaceuticals (F), Allergan (F), InnFocus (F), Mati Therapeutics (F); Brent Siesky, None
  • Footnotes
    Support  Research to Prevent Blindness NY, NY
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 352. doi:
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      Rachel Frantz, Alon Harris, Alice Chandra Verticchio Vercellin, Nicholas Moore, Tyler Joseph Knight, Betul Kaskan, George Eckert, Darrell WuDunn, Brent A Siesky; Functional and structural glaucoma progression after five years in patients with lowered intraocular pressure. Invest. Ophthalmol. Vis. Sci. 2016;57(12):352.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the longitudinal changes in intraocular pressure (IOP) and functional and structural parameters in open-angle glaucoma (OAG) patients over a five-year period

Methods : 111 patients (mean age 65 ± 10.9 years; 68 female, 43 male) with OAG were assessed for changes in IOP, visual fields were evaluated by Humphrey 24-2, and optic nerve head morphology was assessed by Heidelberg retinal tomography 3 every six months for five years. Mixed-model ANCOVA was used to test for statistically significant changes from baseline to five-year follow-up.

Results : IOP decreased from baseline 16.7 to 15.3 at five years, mean change of -1.4 (95% CI: -2.4, -0.5). Mean deviation decreased from -3.4 to -4.9, change of -1.5 (-2.4, -0.6). Pattern standard deviation increased from 4.0 to 4.9, change of 0.9 (0.4, 1.3). Advanced Glaucoma Intervention Study score increased from 1.4 to 2.1, change of 0.6 (0.3, 0.8) (p<0.05).
Structural changes were also observed from baseline to five years, respectively: cup volume increased from 0.296 to 0.319, change of 0.023 (0.003, 0.042); cup/disc area ratio increased from 0.410 to 0.429, change of 0.019 (0.000, 0.038); mean cup depth increased from 0.300 to 0.309, change of 0.009 (0.001, 0.018); cup shape increased from -0.128 to -0.115, change of 0.014 (0.004, 0.024); height variation contour increased from 0.330 to 0.353, change of 0.022 (0.004, 0.040) (p<0.05).

Conclusions : In OAG patients monitored from baseline to five years, visual function worsened and structural damage progressed, despite an overall decrease in IOP. These findings indicate that other factors, besides IOP, influence both structural and functional disease progression.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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