September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Structure/Function Correlation of Optical Coherence Tomography in the Central and Peripheral Visual Fields
Author Affiliations & Notes
  • Eric Lee
    Neuro-Ophthalmology , University of Iowa, Iowa City , Iowa, United States
  • Robert Wanzek
    Neuro-Ophthalmology , University of Iowa, Iowa City , Iowa, United States
  • Andrew Turpin
    Computing and Information Systems, University of Melbourne, Melborne, Victoria, Australia
  • Luke Chong
    Computing and Information Systems, University of Melbourne, Melborne, Victoria, Australia
  • Trina Eden
    Neuro-Ophthalmology , University of Iowa, Iowa City , Iowa, United States
  • Michael Wall
    Neuro-Ophthalmology , University of Iowa, Iowa City , Iowa, United States
  • Footnotes
    Commercial Relationships   Eric Lee, None; Robert Wanzek, None; Andrew Turpin, None; Luke Chong, None; Trina Eden, None; Michael Wall, None
  • Footnotes
    Support  VA Merit Review Grant
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 360. doi:
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    • Get Citation

      Eric Lee, Robert Wanzek, Andrew Turpin, Luke Chong, Trina Eden, Michael Wall; Structure/Function Correlation of Optical Coherence Tomography in the Central and Peripheral Visual Fields. Invest. Ophthalmol. Vis. Sci. 2016;57(12):360.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The peripheral visual field is largely unexplored with static threshold automated perimetry, and little is known about the association between OCT structural data and visual field function in the far periphery. The aim of this study was to quantify the structure-function associations of the far peripheral visual field and compare it against that in the central field to see whether peripheral visual-field assessment improves structure /function correlation of patients with glaucoma.

Methods : 62 ocular- healthy control subjects were recruited to assemble a normative database using the Open Perimetry Interface on the Octopus 900 Perimeter. The CRAN R visualFields package was used for the development of normative values. Control subjects completed 2 visits where they were given 4 perimetry tests: OPI 30-2 size III, OPI 30-2 size V, OPI peripheral size V, and OPI peripheral size VI. 11 glaucoma subjects with mild vision loss (mean deviation worse than -4 dB) on a SITA standard test were given the 4 perimetry tests. All subjects were also tested with Cirrus OCT to measure retinal nerve fiber layer (RNFL) thickness and ganglion cell layer thickness. Two observers assigned qualitative grades of poor, fair, good, and excellent to each type of visual field test based on their level of association with OCT RNFL thickness and ganglion cell thickness and adjudicated any differences. Values were then assigned to each level of association (poor=1, fair=2, good=3, excellent=4).

Results : OCT data associated best with the peripheral V test for 4 glaucoma subjects. Central visual field tests associated best for 5 glaucoma subjects. On 2 occasions, central and peripheral tests correlated equally well with OCT data. Assigning values to each grade of association and averaging the numbers for the 11 comparisons yielded the following results: SITA 30–2 III = 2.36, OPI Peripheral V = 2.55, OPI 30-2 III = 2.45, OPI 30-2 V = 2.64; the differences were not significant.

Conclusions : The central and peripheral visual field assessments both add important data for structure / function correlations. Adding an automated perimetry test of the far periphery may have important clinical utility.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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