September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Assessment of transepidermal water loss of the ocular surface and periorbital skin in dry eye patients.
Author Affiliations & Notes
  • Hyun Sun Jeon
    Ophthalmology, Seoul National University Bundang Hospital, Seongnam-si, Korea (the Republic of)
  • Sang Woong Youn
    Dermatology, Seoul National University Bundang Hospital, Seongnam-si, Korea (the Republic of)
  • Hee Eun Jeon
    Ophthalmology, Seoul National University Bundang Hospital, Seongnam-si, Korea (the Republic of)
  • Joon-Young Hyon
    Ophthalmology, Seoul National University Bundang Hospital, Seongnam-si, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Hyun Sun Jeon, None; Sang Woong Youn, None; Hee Eun Jeon, None; Joon-Young Hyon, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 427. doi:
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      Hyun Sun Jeon, Sang Woong Youn, Hee Eun Jeon, Joon-Young Hyon; Assessment of transepidermal water loss of the ocular surface and periorbital skin in dry eye patients.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):427.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare the transepidermal water loss (TEWL) of the ocular surface and periorbital skin in normal eyes with dry eyes.

Methods : Twenty-eight eyes of 28 dry eye patients were studied and nineteen eyes of 19 normal subjects were examined as control. TEWL was evaluated using ventilated chamber evaporimeter system while the subjects’ eyes with both opened and closed. Tear film break-up time (BUT), schirmer I test, ocular staining score (OSS), tear osmolarity, OSDI, and VAS were also evaluated.

Results : TEWL while eyes opened of dry eye group (63.03 +/- 10.99) were significantly higher than those of the control group (54.74 +/- 14.11; p = 0.014). TEWL while eyes closed of dry eye group (51.93 +/- 11.76) were significantly higher than those of the control group (42.82 +/- 11.99; p = 0.007). BUT (p < 0.001), schirmer I test (p < 0.001), OSS (p < 0.001), tear osmolarity (p = 0.018), OSDI (p < 0.001), and VAS (p < 0.001) were also significantly worse in dry eye group.

Conclusions : TEWL both with eyes opened and closed were higher in dry eye group compared with the control group. TEWL could be considered as a tool of diagnosis of dry eye in conjunction with other dry eye parameters.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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