September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Long-Depth-Range Swept-Source OCT Instrument for Imaging Crystalline Lens Opacities
Author Affiliations & Notes
  • Ireneusz Grulkowski
    Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Torun, Poland
  • Lukasz Cwiklinski
    Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Torun, Poland
  • Silvestre Manzanera
    Laboratorio de Óptica, Universidad de Murcia, Murcia, Spain
  • Juan Mompeán
    Laboratorio de Óptica, Universidad de Murcia, Murcia, Spain
  • Pablo Artal
    Laboratorio de Óptica, Universidad de Murcia, Murcia, Spain
  • Maciej D Wojtkowski
    Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Torun, Poland
  • Footnotes
    Commercial Relationships   Ireneusz Grulkowski, None; Lukasz Cwiklinski, None; Silvestre Manzanera, None; Juan Mompeán, None; Pablo Artal, None; Maciej Wojtkowski, None
  • Footnotes
    Support  European Research Council SEECAT Grant ERC-2013-AdG-339228 & SEIDI Grant, Spain FIS2013-41237-R; Foundation for Polish Science TEAM Grant TEAM/2011-8/8; Polish Ministry of Science and Higher Education Grant IUVENTUS PLUS IP2014 014073
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 437. doi:
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      Ireneusz Grulkowski, Lukasz Cwiklinski, Silvestre Manzanera, Juan Mompeán, Pablo Artal, Maciej D Wojtkowski; Long-Depth-Range Swept-Source OCT Instrument for Imaging Crystalline Lens Opacities. Invest. Ophthalmol. Vis. Sci. 2016;57(12):437.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : In early cataracts, the crystalline lens presents some subtle opacifications causing an increase in scattering and a reduction in quality of vision. We have developed a long-range swept source OCT utilizing short external cavity wavelength tunable laser technology for in vivo three-dimensional (3-D) imaging of the crystalline lens to detect opacifications.

Methods : A high speed swept-source OCT instrument operating at 1050 nm for long-range imaging was developed and optimized for full anterior segment visualization. Imaging of the cornea and the crystalline lens at 50 kHz axial scan rate with 17 mm depth range was performed. OCT volumetric data sets consisting of 350x350 A-scans and covering 7x7 mm2 area (iris area) were acquired. Different contrast parameters were explored in post-processing to effectively visualize the opacities in the crystalline lens. 3-D rendering of spatially resolved scattering within the lens were produced.

Results : We characterized the performance of the OCT system to minimize signal drop with depth (-6 dB at 10 mm depth) and achieve high sensitivity (102 dB). The swept light source used in the OCT system had enhanced coherence length leading to low signal drop. We obtained volumetric OCT tomograms spanning the depth of the entire anterior segment for 3-D visualization of the scattering properties of the crystalline lens. The opacities are characterized by enhanced scattering and generate shadows in cross-sectional images of the crystalline lens, which enables their effective mapping. Eyes with different types and degree of cataract severity were measured.

Conclusions : 3-D long-depth-range Swept-Source OCT enables volumetric visualization in vivo microstructural changes in the crystalline lens related to opacification. This instrument might be a useful tool in the evaluation and management of crystalline lens opacities in cataract patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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