September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Twelve months outcomes of ranibizumab vs. aflibercept for neovascular age-related macular degeneration: observational study data
Author Affiliations & Notes
  • Mark C Gillies
    Ophthalmology, University of Sydney, Sydney, New South Wales, Australia
  • Richard Walton
    Ophthalmology, University of Sydney, Sydney, New South Wales, Australia
  • Jennifer Arnold
    Marsden Eye Specialists, Parramatta, New South Wales, Australia
  • Rohan Essex
    Department of Ophthalmology, Canberra Hospital, Garran, Australian Capital Territory, Australia
  • Nigel Morlet
    Department of Population Health, University of Western Australia, Perth , Western Australia, Australia
  • Daniel Barthelmes
    Ophthalmology, University of Sydney, Sydney, New South Wales, Australia
    Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Switzerland
  • Footnotes
    Commercial Relationships   Mark Gillies, Bayer (F), Bayer (R), Novartis (F), Novartis (R); Richard Walton, None; Jennifer Arnold, Alcon (R), Bayer (R), Novartis (R); Rohan Essex, None; Nigel Morlet, None; Daniel Barthelmes, None
  • Footnotes
    Support  Supported by a grant from the Royal Australian NZ College of Ophthalmologists Eye Foundation (2007-2009) and a grant from the National Health and Medical Research Council, Australia (NHRMC 2010-1012). Daniel Barthelmes and Mark Gillies are among owners of the copyright for the software with which the data for this project was collected. The other authors state they have no conflicts of interest to declare. Mark Gillies is a Sydney Medical Foundation Fellow and is supported by an NHMRC practitioner fellowship. Daniel Barthelmes was supported by the Walter and Gertrud Siegenthaler Foundation Zurich, Switzerland, the Holcim Foundation and the Swiss National Foundation.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 523. doi:
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      Mark C Gillies, Richard Walton, Jennifer Arnold, Rohan Essex, Nigel Morlet, Daniel Barthelmes; Twelve months outcomes of ranibizumab vs. aflibercept for neovascular age-related macular degeneration: observational study data. Invest. Ophthalmol. Vis. Sci. 2016;57(12):523.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare the 12-month outcomes of ranibizumab vs. aflibercept therapy for treatment-naïve eyes with neovascular age-related macular degeneration (nAMD) in routine clinical practice.

Methods : Eyes commencing treatment over a 10 month recruitment period (01-Dec-2013 to 30-Sep-2014) formed the study population. The primary study outcome was mean change in visual acuity (VA) over 12 months. Secondary outcomes included the proportion of eyes in which the lesion became inactive and the number of injections to first recorded grading as inactive.

Results : The study population consisted of 261 eyes of 252 patients treated at 26 practices. Accrual rates over the 10 month recruitment period were similar resulting in similar sized groups (n=131 ranibizumab and n=130 aflibercept). Demographics and clinical characteristics were similar for both groups with mean index VA of 64.2 (ranibizumab) and 62.4 (aflibercept) LogMAR letters. The only significant difference was that the ranibizumab group mean age was 3.8 years older. Group mean 12 month VA outcomes for eyes which completed the study period were similar. The treatment-by-time interaction from the longitudinal model provided no evidence for a difference between the two groups (P=0.456). Group mean VA at 12 months were similar: 70.1 (ranibizumab) vs 68.5 (aflibercept) letters (P=0.604; t-test). Eyes which completed the study period had an average of 8.6 (ranibizumab) and 8.1 (aflibercept) injections (P=0.860, Conway-Maxwell Poisson) and an average of 10.0 (ranibizumab) and 10.1 (aflibercept) visits.

Conclusions : We found no difference in the efficacy of ranibizumab vs aflibercept for nAMD in this observational study. Further studies are warranted to determine, for example by genetic testing, whether either agent is superior for individual eyes.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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