September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Unexpected functional roles of horizontal cells in the retinal circuit
Author Affiliations & Notes
  • Taro Chaya
    Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Suita, Osaka, Japan
  • Akihiro Matsumoto
    Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Yuko Sugita
    Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Suita, Osaka, Japan
  • Satoshi Watanabe
    Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Suita, Osaka, Japan
  • Ryusuke Kuwahara
    Research Center for Ultrahigh Voltage Electron Microscopy, Osaka University, Ibaraki, Osaka, Japan
  • Masao Tachibana
    Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Takahisa Furukawa
    Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Suita, Osaka, Japan
  • Footnotes
    Commercial Relationships   Taro Chaya, None; Akihiro Matsumoto, None; Yuko Sugita, None; Satoshi Watanabe, None; Ryusuke Kuwahara, None; Masao Tachibana, None; Takahisa Furukawa, None
  • Footnotes
    Support  Grant-in-Aid for Young Scientists (B) from Japan Society for the Promotion of Science, The Takeda Science Foundation, and The Uehara Memorial Foundation
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 589. doi:
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    • Get Citation

      Taro Chaya, Akihiro Matsumoto, Yuko Sugita, Satoshi Watanabe, Ryusuke Kuwahara, Masao Tachibana, Takahisa Furukawa; Unexpected functional roles of horizontal cells in the retinal circuit. Invest. Ophthalmol. Vis. Sci. 2016;57(12):589.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Interneurons play pivotal roles in information processing in the neural circuit. Retinal horizontal cells (HCs) are inhibitory interneurons that are known to be involved in lateral inhibition to increase spatial resolution in vision. However, exact functional roles of HCs in the retina still remain unclear.

Methods : We established HC depletion (dHC) mice and analyzed electrophysiological properties of dHC retinas under non-degenerative condition of the retina.

Results : Depletion of HCs resulted in impairment of firing properties and functional subtype formation of retinal ganglion cells (RGCs) in addition to enlargement of receptive field of RGCs. Furthermore, we found that HCs play an essential role in global light adaptation. At an individual level, dHC mice exhibited abnormal visual function in optokinetic responses.

Conclusions : Our current study uncovers versatile functional roles of HCs in the retinal circuit.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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