September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Color vision, dark adaptation and retinal structure in Aniridia
Author Affiliations & Notes
  • Hilde Røgeberg Pedersen
    Department of Optometry and Visual Science, University College of Southeast Norway, Kongsberg, Norway
  • Lene Aarvelta Hagen
    Department of Optometry and Visual Science, University College of Southeast Norway, Kongsberg, Norway
  • Erlend Sommer Landsend
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
  • Jon V. B. Gjelle
    Department of Optometry and Visual Science, University College of Southeast Norway, Kongsberg, Norway
  • Øygunn Aass Utheim
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
  • Stuart J. Gilson
    Department of Optometry and Visual Science, University College of Southeast Norway, Kongsberg, Norway
  • Tor Paaske Utheim
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
    Institute of Oral Biology, University of Oslo, Oslo, Norway
  • Rigmor C Baraas
    Department of Optometry and Visual Science, University College of Southeast Norway, Kongsberg, Norway
  • Footnotes
    Commercial Relationships   Hilde Pedersen, None; Lene Hagen, None; Erlend Landsend, None; Jon Gjelle, None; Øygunn Utheim, None; Stuart Gilson, None; Tor Utheim, None; Rigmor Baraas, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 623. doi:
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      Hilde Røgeberg Pedersen, Lene Aarvelta Hagen, Erlend Sommer Landsend, Jon V. B. Gjelle, Øygunn Aass Utheim, Stuart J. Gilson, Tor Paaske Utheim, Rigmor C Baraas; Color vision, dark adaptation and retinal structure in Aniridia. Invest. Ophthalmol. Vis. Sci. 2016;57(12):623.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate color vision, dark adaptation and retinal structure in individuals with aniridia

Methods : Twenty-seven males and females, aged 11–67 yrs, with aniridia were included in the study. Color vision was examined with HRR pseudo-isochromatic plates (4th ed., 2002) and the Color Assessment and Diagnosis (CAD) test. Observers viewed the CAD stimulus binocularly with optimal optical correction from a 1.4 m distance. Stimuli size was 2.2 deg with increased luminance noise and slower speed to mask rod intrusion. Color-vision deficiency (CVD) was defined if CAD thresholds in standard normal units (SNU) > 2.5. Rod and cone mediated dark adaptation (DA) were measured with the Roland Consult DarkAdaptometer after a 5 min photobleach (7000 cd/m2) with fixation target at 20 deg temporal eccentricity. Speed of DA was characterized by the time to the rod-cone break (TRCB). Visual acuity (VA), corneal and lens opacities were assessed. Retinal straylight was measured with the Oculus C-Quant using the compensation comparison method. The central 30 deg of both eyes were imaged with the Heidelberg Spectralis OCT. Foveal, para- and perifoveal retinal layers and severity of foveal hypoplasia (FH) were analyzed by calculating longitudinal reflectivity profiles (LRP) after correction of scaling for individual axial length.

Results : VA ranged from logMAR 0.00–1.76. Two subjects were classified with tritan and three with red-green (RG) CVD on the HRR. Five males and 13 females were classified to have a RG CVD on the CAD (RG threshold 2.6–16.6 [SNU]). Three of these were also classified with tritan CVD (YB threshold 4.5–11.6 [SNU]), including the two HRR-classified tritans. The three with RG CVD on the HRR had CAD RG of 3.1, 4.9 and 8.4. TRCB was normal compared with age-matched controls. Measurements of retinal thickness, relative lengthening of the photoreceptor layer and outer nuclear layer, showed a considerable variation in FH grade. A significant positive correlation was found between FH severity, logMAR VA (p<0.001) and RG threshold (p=0.02). LogMAR VA, RG and YB thresholds increased with keratopathy severity (all p<0.05). No significant correlations were found between RG threshold and age, lens opacities or retinal straylight.

Conclusions : The results suggest that the observed red-green deficiencies may be secondary to foveal hypoplasia as a consequence of a central structural organization that is similar to that in normal perifovea.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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