September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Analysis of Retinal nerve fiber layer in Mild cognitive impairment and Alzheimer disease.
Author Affiliations & Notes
  • Do Gyun Kim
    ophthalmology, Myong-ji Hospital, Seonam University Medical college, Goyang-si,Gyenoggi- do, Korea (the Republic of)
  • Jin Young Kwon
    ophthalmology, Myong-ji Hospital, Seonam University Medical college, Goyang-si,Gyenoggi- do, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Do Gyun Kim, None; Jin Young Kwon, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 629. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Do Gyun Kim, Jin Young Kwon; Analysis of Retinal nerve fiber layer in Mild cognitive impairment and Alzheimer disease.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):629.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To compare the retinal nerve fiber layer (RNFL) and macula in the eyes of healthy older persons with no cognitive disabilities with that in the eyes of older people with mild cognitive impairment (MCI) or Alzheimer’s Disease (AD) using optical coherence tomography (OCT) to determine its effectiveness for early diagnosis of MCI or AD

Methods : Thirty eyes of 30 subjects in each cohort of normal eyes and those in patients with MCI or AD were studied. All subjects underwent ophthalmologic and cognitive examinations and measurements of RNFL thickness, and macular volume and thickness using OCT.

Results : Mean RNFL thickness on OCT was significantly thinner in the AD group than in the MCI group (p = 0.01). The RNFL was thinner in the superior quadrant in patients with AD compared to the healthy controls (p = 0.03). The RNFL thickness in the inferior, nasal, and temporal quadrants did not differ significantly among groups. Measurements in 12 zones revealed that zone 11 had a significantly thinner RNFL in the AD group compared with the healthy control group (p = 0.02). In zone 2, the MCI group had a significantly thinner RNFL than the AD group (p = 0.03).

Conclusions : Our findings revealed a neuroanatomic difference in the RNFL thickness among the three groups of AD, MCI and healthy controls on OCT, suggesting that a change in the average RNFL thickness could be one of several meaningful index for implying early AD .

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×