September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Vitreous concentrations of VEGF family indicate visual prognosis after vitrectomy in patients with rhegmatogenous retinal detachment
Author Affiliations & Notes
  • Masahiko Shimura
    Ophthalmology, Tokyo Medical University, Hachioji Medical Center, Hachioji, Tokyo, Japan
  • Ryosuke Motohashi
    Ophthalmology, Tokyo Medical University, Hachioji Medical Center, Hachioji, Tokyo, Japan
  • Kanako Yasuda
    Ophthalmology, Tokyo Medical University, Hachioji Medical Center, Hachioji, Tokyo, Japan
  • Hidetaka Noma
    Ophthalmology, Tokyo Medical University, Hachioji Medical Center, Hachioji, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Masahiko Shimura, None; Ryosuke Motohashi, None; Kanako Yasuda, None; Hidetaka Noma, None
  • Footnotes
    Support  JSPS KAKENHI grant number 15K10849
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1028. doi:
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    • Get Citation

      Masahiko Shimura, Ryosuke Motohashi, Kanako Yasuda, Hidetaka Noma; Vitreous concentrations of VEGF family indicate visual prognosis after vitrectomy in patients with rhegmatogenous retinal detachment. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1028.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Even if successfully reattachment after vitrectomy in eyes with rhegmatogenous retinal detachment, complete recovery of visual function does not always obtain in some cases. In this study, the relationships between visual prognosis and the vitreous concentrations of certain cytokines were investigated.

Methods : Thirty eyes of 30 patients with rhegmatogenous retinal detachment which obtained complete morphological recovery after vitrectomy were investigated. Vitreous sample in each eye was obtained at the time of the surgery and the concentrations of cytokines including VEGF, PlGF, VEGF receptor-1 (VEGFR1), VEGFR2, MCP-1, ICAM-1, PDGF, IL-6, IL-8, IL-12, and IP-10 were measured by enzyme linked assay (ELISA). LogMAR visual acuity at postoperative 6 months (post VA) was also recorded.

Results : At the time of surgery, foveal detachment was seen in 22 eyes, 12 eyes of which were obtained post VA better than logMAR0.3 (Group A) and 10 eyes of post VA worse than 0.3 (Group B). Remaining 8 eyes showed foveal attachment at the surgery and all 8 eyes obtained post VA better than logMAR 0.3 (Group C). According to one way ANOVA analysis, vitreous concentrations of VEGF and PlGF were significantly increased in Group A (p=0.034, 0.041), while VEGFR1 and R2 in group A and B were higher than those in group C.

Conclusions : Higher vitreous concentrations of VEGF family indicate worse visual prognosis even after complete morphological recovery after vitrectomy in eyes with rhegmatogenous retinal detachment.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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