September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Circumpapillary Retinal Nerve Fiber Layer Thickness, Anterior Lamina Cribrosa Depth, and Lamina Cribrosa Thickness in Neovascular Glaucoma Secondary to Diabetic Retinopathy
Author Affiliations & Notes
  • Satoshi Yokota
    Ophthalmology, University of Fukui, Fukui, Japan
    Ophthalmology and Visual Sciences, Kyoto University, Kyoto, Japan
  • Yuji Takihara
    Ophthalmology, University of Fukui, Fukui, Japan
  • Yoshihiro Takamura
    Ophthalmology, University of Fukui, Fukui, Japan
  • Masaru Inatani
    Ophthalmology, University of Fukui, Fukui, Japan
  • Footnotes
    Commercial Relationships   Satoshi Yokota, None; Yuji Takihara, None; Yoshihiro Takamura, None; Masaru Inatani, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 833. doi:
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      Satoshi Yokota, Yuji Takihara, Yoshihiro Takamura, Masaru Inatani; Circumpapillary Retinal Nerve Fiber Layer Thickness, Anterior Lamina Cribrosa Depth, and Lamina Cribrosa Thickness in Neovascular Glaucoma Secondary to Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):833.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Diabetes itself and pan-retinal photocoagulation (PRP) reduce retinal nerve fiber layer thickness. Neovascular glaucoma (NVG) also damages reinal ganglin cells. To clarify the difference between NVG and other subtypes of glaucoma, we analyzed circumpapillary retinal nerve fiber layer (cpRNFL) thickness, anterior lamina cribrosa depth (ALD), and laminar cribrosa thickness (LCT).

Methods : Forty-four patients with proliferative diabetic retinopathy (PDR) who had previously undergone PRP were enrolled in a cross-sectional study. Patients were divided into 2 groups according to absence or presence of NVG (non-NVG group and NVG group, respectively). Between 2 groups, cpRNFL thickness, ALD, and LCT were compared.

Results : In non-NVG group, age was 63.5 ± 2.4 (mean ± standard error) years, cpRNFL thickness was 89.8 ± 3.9 µm, ALD was 400.9 ± 22.5 µm and LCT was 153.7 ± 5.7 µm. In NVG group, age was 63.8 ± 2.4 years, cpRNFL thickness was 76.4 ± 3.8 µm, ALD was 416.9 ± 22.5 µm, and LCT was 158.7 ± 4.3 µm. CpRNFL thickness in NVG group was significantly thinner than that in non-NVG group (P < 0.012). However, age, ALD, and LCT were not statistically different between the groups (P = 0.947, 0.617, and 0.407, respectively).

Conclusions : Compared with cpRNFL change, changes in lamina cribrosa were small in the NVG patients secondary to PDR. In NVG patients, retinal ganglion cell vulnerability due to retinal ischemia may contribute to axonal damage prior to lamina cribrosa deformation.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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