September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Assessment of glaucoma progression by Cirrus optical coherence tomography-guided progression analysis
Author Affiliations & Notes
  • Martha Kim
    Department of Ophthalmology, Dongguk University Ilsan Hosipital, Goyang, Gyeonggi-do, Korea (the Republic of)
  • Choul Yong Park
    Department of Ophthalmology, Dongguk University Ilsan Hosipital, Goyang, Gyeonggi-do, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Martha Kim, None; Choul Yong Park, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 846. doi:
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      Martha Kim, Choul Yong Park; Assessment of glaucoma progression by Cirrus optical coherence tomography-guided progression analysis. Invest. Ophthalmol. Vis. Sci. 2016;57(12):846.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the value of Cirrus spectral domain optical coherence tomography (SD-OCT)-guided progression analysis (GPA) to detect glaucoma progression, and to find factors associated with the diagnostic accuracy of SD-CT GPA assessment.

Methods : This retrospective study included 68 eyes of 68 glaucoma patients. All patients underwent SD-OCT measurements more than 3 times with 6-month intervals. Glaucoma progression was assessed using SD-OCT GPA software. Conventional glaucoma progression assessment was also performed using a red-free retinal nerve fiber layer photography and Humphrey visual field test (HVF).

Results : The mean age of subjects was 57.4 ± 12.4 years old and the mean follow-up period was 49.4 ± 25.1 months. Of the 68 eyes, 28 eyes (41.2%) showed glaucoma progression based on conventional assessment, while 32 eyes (47.1%) showed progression based on SD-OCT GPA assessment. Using the conventional method as a gold standard for the detection of glaucoma progression, the false-positive rate and the false-negative rate were 60.7% and 52.5%, retrospectively, for SD-OCT GPA assessment. Factors associated with false-positive and false-negative results were signal strength of less than 6 on multivariate logistic regression analysis (P = 0.014 and P = 0.023, respectively).

Conclusions : In patients with glaucoma, it seems insufficient to determine the disease progression using the SD-OCT GPA assessment only, especially in cases with low signal strength.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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