September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Long Axial Length Normative Database in Optic Coherence Tomography for Glaucoma Diagnosis in Eyes with High Myopia
Author Affiliations & Notes
  • Yu-fan Chang
    Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
    School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • Catherine Jui-Ling Liu
    Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
    School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • Yu-Chieh Ko
    Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
    School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • Chih-Chien Hsu
    Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
    School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • Mei-ju Chen
    Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
    School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • Footnotes
    Commercial Relationships   Yu-fan Chang, None; Catherine Jui-Ling Liu, None; Yu-Chieh Ko, None; Chih-Chien Hsu, None; Mei-ju Chen, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 865. doi:
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      Yu-fan Chang, Catherine Jui-Ling Liu, Yu-Chieh Ko, Chih-Chien Hsu, Mei-ju Chen; Long Axial Length Normative Database in Optic Coherence Tomography for Glaucoma Diagnosis in Eyes with High Myopia. Invest. Ophthalmol. Vis. Sci. 2016;57(12):865.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We compared the diagnostic ability of glaucoma, and false positive and false negative rate of glaucoma diagnosis in high myopic eyes using two different optic coherence tomography (OCT) devices: RS-3000 SD-OCT and Cirrus HD-OCT.

Methods : This is a prospective, comparative study. Fourty control eyes and 41 primary open angle glaucoma (POAG) eyes with AL ≥ 26mm were enrolled from September 2014 to May 2015. The circumperipapillary RNFL (cpRNFL) and ganglion cell analysis (GCA) measurements were done. Receiver operating characteristic (ROC) curve was calculated, and the false-positive rate in healthy myopic group and false-negative rate in POAG myopic group were compared based on the color coding of each devices.

Results : Both devices showed the average RNFL and clock-hour 7 RNFL performed better than other parameters in cpRNFL analysis. In GCA map, the AUROC of all parameters were comparable between RS-3000 OCT (0.778 to 0.873) and that in Cirrus-HD OCT (0.683 to 0.840). The nasal-inferior outer sector (AUROC 0.873, 95% CI 0.795-0.951) and the inferior-temporal sector (AUROC 0.840, 95% CI 0.750-0.930) were the best parameters in RS-3000 OCT and Cirrus-HD OCT, respectively. The GCA map in RS-3000 OCT had lower false-positive rate in glaucoma detection than those in Cirrus HD-OCT.

Conclusions : Diagnostic ability of high myopic glaucoma using cpRNFL parameters is comparable between RS-3000 OCT and Cirrus HD-OCT. The long AL normative database built-in in RS-3000 is useful in improving GCA map diagnostic ability, and reducing the false positive rate of macular parameters in glaucoma diagnosis for eyes with AL ≥ 26 mm.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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