September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Superior-Inferior Asymmetry in Ganglion Cell-Inner Plexiform Layer Thickness Assessed by Spectrum Domain Optic Coherent Tomography in Glaucoma
Author Affiliations & Notes
  • Catherine Liu
    Taipei Veterans General Hospital, Taipei, Taiwan
    National Yang-Ming University, Taipei, Taiwan
  • Yu-fan Chang
    Taipei Veterans General Hospital, Taipei, Taiwan
    National Yang-Ming University, Taipei, Taiwan
  • Yu-Chieh Ko
    Taipei Veterans General Hospital, Taipei, Taiwan
    National Yang-Ming University, Taipei, Taiwan
  • Mei-ju Chen
    Taipei Veterans General Hospital, Taipei, Taiwan
    National Yang-Ming University, Taipei, Taiwan
  • Chih-Chien Hsu
    Taipei Veterans General Hospital, Taipei, Taiwan
    National Yang-Ming University, Taipei, Taiwan
  • Nah-Wen Fan
    Taipei Veterans General Hospital, Taipei, Taiwan
    National Yang-Ming University, Taipei, Taiwan
  • Footnotes
    Commercial Relationships   Catherine Liu, None; Yu-fan Chang, None; Yu-Chieh Ko, None; Mei-ju Chen, None; Chih-Chien Hsu, None; Nah-Wen Fan, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 868. doi:
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      Catherine Liu, Yu-fan Chang, Yu-Chieh Ko, Mei-ju Chen, Chih-Chien Hsu, Nah-Wen Fan; Superior-Inferior Asymmetry in Ganglion Cell-Inner Plexiform Layer Thickness Assessed by Spectrum Domain Optic Coherent Tomography in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2016;57(12):868.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : This study aimed to determine whether asymmetry between the superior and inferior macular ganglion cell-inner plexiform layer (GC-IPL) thickness in Cirrus-HD OCT provide a clue to early structural change of glaucoma.

Methods : Subjects with primary open angle glaucoma (POAG), glaucoma suspect, and normal healthy eyes were recruited from February 2013 and January 2014. The absolute value of the difference between the inferior and superior thickness (I-S difference) was regarded as asymmetry in GC-IPL thickness. We calculated the area under the receiver operating characteristic curve (AUROC) of the absolute I-S difference over the whole macular imaging area, as well as of the temporal and nasal sectors to determine their diagnostic ability in glaucoma.

Results : A total of 269 POAG eyes, 122 eyes with glaucoma suspect, and 105 normal control eyes were included. The AUROC of the cpRNFL parameters showed the best performance in clock-hour 7 (AUROC=0.89), while minimum GC-IPL (AUROC=0.86) and temporal-inferior sectors (AUROC=0.86) stood out among all the GC-IPL parameters. The AUROC of total GC-IPL (I-S difference), temporal (I-S difference), and nasal (I-S difference) were 0.76, 0.76, and 0.67, respectively. When only early POAG with a VF mean deviation no worse than -6.0 dB (173 eyes) were considered, the AUROC of the clock-hour 7 cpRNFL parameter became 0.84, of minimum GC-IPL becaome 0.81, and of temporal-inferior GC-IPL sector became 0.80.

Conclusions : While diagnosis ability decreased in all cpRNFL and GC-IPL parameters for early glaucoma, AUROC of total GC-IPL (I-S difference) and temporal GC-IPL (I-S difference) remained similar (0.77).

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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