September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Enhanced repeatability by B-scan averaging in measurement of macular ganglion cell complex with spectral-domain optical coherence tomography in glaucomatous eye.
Author Affiliations & Notes
  • Sayaka Adachi
    Ophthalmology - CERES, Keio University, Shinjyukuku, Japan
  • Daisuke Shiba
    Ophthalmology - CERES, Keio University, Shinjyukuku, Japan
  • Eri Hirano
    Ophthalmology - CERES, Keio University, Shinjyukuku, Japan
  • Takeshi Ono
    Ophthalmology - CERES, Keio University, Shinjyukuku, Japan
  • Kenya Yuki
    Ophthalmology - CERES, Keio University, Shinjyukuku, Japan
  • Kazuo Tsubota
    Ophthalmology - CERES, Keio University, Shinjyukuku, Japan
  • Footnotes
    Commercial Relationships   Sayaka Adachi, None; Daisuke Shiba, None; Eri Hirano, None; Takeshi Ono, None; Kenya Yuki, None; Kazuo Tsubota, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 873. doi:
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      Sayaka Adachi, Daisuke Shiba, Eri Hirano, Takeshi Ono, Kenya Yuki, Kazuo Tsubota; Enhanced repeatability by B-scan averaging in measurement of macular ganglion cell complex with spectral-domain optical coherence tomography in glaucomatous eye.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):873.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Some spectral-domain optical coherence tomography (SD-OCT) have an eye-tracking system and averaging multiple B-scan system to improve measurement precision and image quality. These technologies, however, have been applied only in B-scan mode. We investigated whether the two technologies can improve repeatability of volume measurements of macular ganglion cell complex (GCC) in glaucomatous eye.

Methods : We included primary open angle glaucoma patients with mean deviation value above -18dB in this prospective observational study. Patient with any other intraocular disorder or history of intraocular surgery except successful glaucoma surgery was excluded. If both eyes were eligible, one eye was randomly selected. All cases underwent GCC volume measurements with following three methods; A: simple scan, B: scan with eye-tracking, C: averaging multiple B-scan with eye-tracking. The same GCC map measurements were repeated within 2 months. The SD-OCT (Nidek; RS-3000 Advance) can acquire a macular GCC thickness map from 128 B-scans consisted of 512 A-scans in method A, B, C. The eye-tracking system includes real-time positional control of the measurement point based on the retinal blood vessels monitored simultaneously. In method C, the averaged B-scan from 10 B-scans under eye-tracking system was used for the volume analysis. From the GCC thickness map, mean GCC thicknesses were calculated in 3 parts, full circle segment (circle) with a radius of 10 degrees, superior semicircle segment (SSC) and inferior semi-circle segment (ISC) with the same radius. The repeatability of GCC measurement with SD-OCT was evaluated by intra-class correlation coefficient (ICC).

Results : 51 glaucomatous eyes of 51 patients were enrolled in this study.
ICCs [95% CI] of GCC thickness measurements with method A, B, C were:
0.987[0.977-0.992], 0.989[0.982-0.994], 0.992[0.987-0.996] in circle,
0.989[0.980-0.994], 0.991[0.984-0.995], 0.992[0.986-0.995] in SSC,
0.986[0.976-0.992], 0.981[0.967-0.989], 0.995[0.991-0.997] in ISC.

Conclusions : Eye-tracking (Method B) did not yield higher repeatability, but multiple B-scan averaging with eye-tracking (Method C) improved repeatability in measuring GCC by SD-OCT.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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