September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Effect of CACICOL® on corneal epithelial healing after cross-linking in patients with keratoconus
Author Affiliations & Notes
  • Gerhard Garhofer
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
  • Leopold Schmetterer
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Center for Medical Physics and Biomedical Engineering , Medical University of Vienna, Vienna, Austria
  • Katarzyna Witkowska
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Center for Medical Physics and Biomedical Engineering , Medical University of Vienna, Vienna, Austria
  • Piotr Wozniak
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
  • Ahmed Bata
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
  • Klemens Fondi
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
  • Gerald Schmidinger
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Niklas Pircher
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Doreen Schmidl
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
  • Rene Marcel Werkmeister
    Center for Medical Physics and Biomedical Engineering , Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships   Gerhard Garhofer, None; Leopold Schmetterer, None; Katarzyna Witkowska, None; Piotr Wozniak, None; Ahmed Bata, None; Klemens Fondi, None; Gerald Schmidinger, None; Niklas Pircher, None; Doreen Schmidl, None; Rene Werkmeister, None
  • Footnotes
    Support  An unrestricted research grant from Laboratoires Théa is gratefully acknowledged
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 909. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Gerhard Garhofer, Leopold Schmetterer, Katarzyna Witkowska, Piotr Wozniak, Ahmed Bata, Klemens Fondi, Gerald Schmidinger, Niklas Pircher, Doreen Schmidl, Rene Marcel Werkmeister; Effect of CACICOL® on corneal epithelial healing after cross-linking in patients with keratoconus. Invest. Ophthalmol. Vis. Sci. 2016;57(12):909.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : The aim of the present study was to investigate the effect of CACICOL® on corneal epithelial healing after epi-off corneal cross-linking in patients with keratoconus . CACICOL® is an ophthalmic solution based on the technology of RGTAs (ReGeneraTingAgents) consisting of bioengineered analogues of heparan sulphate glycosaminoglycans, that were shown to improve tissue healing.

Methods : Randomized, double-masked, parallel group study. Forty patients with keratoconus undergoing epi-off cross-linking were randomized to receive either CACICOL® or Genteal HA® (hyaluronic acid 0.3%) eye drops added to the standard treatment regimen. Patients received the study eye drops every second day. The primary efficacy outcome was corneal wound healing rate, defined as size of defect over time measured using two independent methods: ultrahigh-resolution OCT and slit lamp photography with fluorescein staining.

Results : Wound healing was significantly faster in patients under CACICOL® therapy (4.3 ± 1.2 days) as compared to Genteal HA® therapy (6.0 ± 2.0 days; p = 0.019 between groups). The corneal wound healing rate was significantly faster in patients under CACICOL® therapy as compared to Genteal HA® therapy. This was demonstrated with both OCT images (p < 0.01) as well as from fluorescein photographs (p < 0.01)

Conclusions : CACICOL® significantly improves epithelial wound healing after epi-off cross-linking in patients with keratoconus. Ultrahigh resolution OCT is an attractive tool to study epithelial corneal wound healing.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×