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Yoko Ogawa; Stem Cells Migration and Immune Mediated Fibrosis in Chronic Ocular GVHD. Invest. Ophthalmol. Vis. Sci. 201657(12):.
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Presentation Description :
Chronic graft-versus-host disease (cGVHD) is a complication characterized by an autoimmune-type reaction in various target organs. In a mouse BMT model, transplantation of mismatched mesenchymal stem cells (MSCs) triggered the onset of ocular cGVHD, and was associated with fibrosis and increased IL-6 secretion. A progeny of donor MSCs may play a role as antigen presenting cells to induce the immune response in ocular cGVHD.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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