September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Stem Cells Migration and Immune Mediated Fibrosis in Chronic Ocular GVHD
Author Affiliations & Notes
  • Yoko Ogawa
    Keio Univ School of Medicine, Shinjuku-Ku, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Yoko Ogawa, None
  • Footnotes
    Support  Japanese Ministry of Education, Science, Sports and Culture, #26462668
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Yoko Ogawa; Stem Cells Migration and Immune Mediated Fibrosis in Chronic Ocular GVHD. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : Chronic graft-versus-host disease (cGVHD) is a complication characterized by an autoimmune-type reaction in various target organs. In a mouse BMT model, transplantation of mismatched mesenchymal stem cells (MSCs) triggered the onset of ocular cGVHD, and was associated with fibrosis and increased IL-6 secretion. A progeny of donor MSCs may play a role as antigen presenting cells to induce the immune response in ocular cGVHD.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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