September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Numerical investigation of glucose transport and corneal metabolism in the anterior chamber in the presence of an iris-fixated intraocular lens
Author Affiliations & Notes
  • Peyman Davvalo Khongar
    Department of Civil, Chemical and Environmental Engineering, University of Genoa , Genoa, Italy
  • Xi Cheng
    Mechanical Engineering, Stanford University, CA, California, United States
  • Jan Oscar Pralits
    Department of Civil, Chemical and Environmental Engineering, University of Genoa , Genoa, Italy
  • Rodolfo Repetto
    Department of Civil, Chemical and Environmental Engineering, University of Genoa , Genoa, Italy
  • Paolo Soleri
    Ophtec BV, Groningen, Netherlands
  • Peter M Pinsky
    Mechanical Engineering, Stanford University, CA, California, United States
  • Footnotes
    Commercial Relationships   Peyman Davvalo Khongar, None; Xi Cheng, None; Jan Pralits, None; Rodolfo Repetto, Ophtec BV (F); Paolo Soleri, Ophtec BV (E); Peter Pinsky, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Peyman Davvalo Khongar, Xi Cheng, Jan Oscar Pralits, Rodolfo Repetto, Paolo Soleri, Peter M Pinsky; Numerical investigation of glucose transport and corneal metabolism in the anterior chamber in the presence of an iris-fixated intraocular lens. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The cause of possible decline of corneal endothelial cell density in the cornea in the presence of intraocular lenses is still poorly understood. We postulate that cell loss might be associated to changes in the glucose concentration that is caused by variations of the aqueous humor flow in the anterior chamber. This hypothesis is tested by mathematically modeling the glucose transport and corneal metabolism in the anterior chamber with and without the presence of an iris-fixted intraocular lens (pIOL).

Methods : We perform numerical simulations of corneal metabolism and transport processes in the anterior chamber, adopting idealized but realistic geometries. We focus our attention on the aqueous flow due to production/drainage that models the case of a person at sleep. In this case, flow induced by eye rotations and thermal effects is absent. In the case of pIOL we also consider the possibility of having a central hole in the lens body.

Results : The concentration of glucose along the corneal endothelium is found to be significantly non-uniform even in the absence of a pIOL, but glucose flux across the endothelium is almost constant along its length. Implantation of a pIOL produces a decrease of glucose availability in the central region of the cornea. Even if the process of glucose consumption takes place over time scales that are longer than the typical interval between rapid eye movements, that would contribute to mix up the aqueous in the anterior chamber, low values of glucose concentration at the cornea are likely to occur.

Conclusions : For a person at sleep nutrient concentration along the corneal endothelium can be significantly non-uniform. Implantation of a pIOL may produce a decrease of nutrient availability in the central region of the cornea, although it must be verified whether this has clinical relevance.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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