September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Intensified topical steroids as prophylaxis for macular edema after posterior lamellar keratoplasty combined with cataract surgery
Author Affiliations & Notes
  • Robert Hoerster
    Department of Ophthalmology, University of Cologne, Cologne , Germany
  • Tisha Prabriputaloong Stanzel
    Department of Ophthalmology, University of Cologne, Cologne , Germany
  • Bjoern O Bachmann
    Department of Ophthalmology, University of Cologne, Cologne , Germany
  • Sebastian E Siebelmann
    Department of Ophthalmology, University of Cologne, Cologne , Germany
  • Moritz Felsch
    Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne , Germany
  • Claus Cursiefen
    Department of Ophthalmology, University of Cologne, Cologne , Germany
  • Footnotes
    Commercial Relationships   Robert Hoerster, None; Tisha Stanzel, None; Bjoern Bachmann, None; Sebastian Siebelmann, None; Moritz Felsch, None; Claus Cursiefen, Gene Signal, Lausanne Switzerland (C), Novaliq, Heidelberg, Germany (C)
  • Footnotes
    Support  (EU): COST BM 1302; FP7 STRONG (www.biocornea.eu); German Research Foundation (DFG) FOR 2240 (www.for2240.de)
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1221. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Robert Hoerster, Tisha Prabriputaloong Stanzel, Bjoern O Bachmann, Sebastian E Siebelmann, Moritz Felsch, Claus Cursiefen; Intensified topical steroids as prophylaxis for macular edema after posterior lamellar keratoplasty combined with cataract surgery. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1221.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To analyze the effect of intensified topical steroid therapy after Descemet’s Membrane Endothelial Keratoplasty combined with cataract surgery (Triple-DMEK) on the incidence of postoperative cystoid macular edema (CME).

Methods : Design: Single center comparative clinical study with historical controls.
<span style="line-height:1.6">Setting: Department of Ophthalmology, University of Cologne, Germany, tertiary hospital, performing 500 corneal transplant surgeries per year.</span>
Patients: 150 eyes of 131 patients undergoing Triple-DMEK surgery. Inclusion criterion: Triple-DMEK surgery. Exclusion criteria: Prior retinal surgery, history of prior CME.
Interventions: Prednisolone acetate eye drops 1% 5 times daily for the first week after surgery. After an internal change of therapy regimen: Prednisolone acetate eye drops 1% hourly for the first postoperative week. We compared 75 consecutive eyes before with 75 consecutive eyes after the change of therapy regimen. Patients received macular spectral domain optical coherence tomography (SD-OCT) preoperatively, as well as 6 weeks, 3 and 6 months post surgery.
Main Outcome Measure: Development of CME detected by macular SD-OCT during 6 months postoperatively.

Results : Both groups were comparable regarding baseline age, gender, central corneal thickness, rebubbling rate and visual acuity. With topical steroid therapy 5 times per day during the first postoperative week, we observed 9 cases of subsequent CME (12%). With hourly topical steroid therapy none of the patients developed CME subsequently (P=0.003). Apart from the topical steroids during first week, medical treatment was identical in both groups.

Conclusions : Early intensified postoperative topical steroid therapy constitutes an effective prophylactic treatment to reduce incidence of CME after Triple-DMEK surgery.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×