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Ahmad M Alaraj, Samar A Al-Swailem; Comparison of lamellar keratoplasty versus penetrating keratoplasty for macular corneal dystrophy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1238.
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© ARVO (1962-2015); The Authors (2016-present)
To compare postoperative outcomes of anterior lamellar keratoplasty (ALK), big-bubble deep anterior Lamellar keratoplasty (DALK) and penetrating keratoplasty (PKP) for macular corneal dystrophy (MCD).
Retrospective analysis of 10 ALK eyes, 24 DALK eyes and 140 PKP eyes in 98 patients with MCD.
Median follow-up was 3.62 (range 1.04-16.02) years and 5.89 (range 1.0-17.0) years in the lamellar keratoplasties and PKP groups, respectively. Median best-corrected visual acuity (BCVA) was 20/80 and 20/40 in ALK and DALK groups, respectively (P=0.006). Median BCVA was 20/40 in PKP group. The likely hood of achieving 20/40 or better was higher in PKP vs. DALK groups, but was not statistically significant. Graft survived in 30% (3 eyes) and 100% (24 eyes) in ALK and DALK groups, respectively (P=0.0001). Graft survived in 95% (133 eyes) in PKP group. Recurrence (71.4%) was the main cause of graft failure in ALK group, while recurrence (42.8%) and irreversible rejection (57.1%) were the main causes of graft failure in PKP group.
ALK for MCD is associated with poor prognosis for graft survival and visual result. In comparison to PKP, DALK has a higher probability of graft survival, a lower complication rate, and a comparable visual result.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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