September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Choroidal and retinal thickness changes after uneventful cataract surgery in patients treated prophylactically with topical ketorolac or bromfenac.
Author Affiliations & Notes
  • Ivo Filipe Gama
    Ophthalmology, Hospital Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon Academic Medical Center, Lisbon University, Lisbon, Portugal
  • Ana Inês Gonçalves
    Ophthalmology, Hospital Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon Academic Medical Center, Lisbon University, Lisbon, Portugal
  • Leonor Duarte Almeida
    Ophthalmology, Hospital Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon Academic Medical Center, Lisbon University, Lisbon, Portugal
  • Manuel Monteiro-Grillo
    Ophthalmology, Hospital Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon Academic Medical Center, Lisbon University, Lisbon, Portugal
  • Footnotes
    Commercial Relationships   Ivo Gama, None; Ana Gonçalves, None; Leonor Almeida, None; Manuel Monteiro-Grillo, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1323. doi:
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      Ivo Filipe Gama, Ana Inês Gonçalves, Leonor Duarte Almeida, Manuel Monteiro-Grillo; Choroidal and retinal thickness changes after uneventful cataract surgery in patients treated prophylactically with topical ketorolac or bromfenac.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1323.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this study was to evaluate the changes of macular and choroidal thickness after uncomplicated cataract surgery, using enhanced depth imaging spectral domain optical coherence tomography (EDI-OCT) in eyes treated prophylactically with topical ketorolac or bromfenac.

Methods : In 20eyes (20patients), macular retinal (RT) and choroidal (CT) thicknesses were measured preoperatively and at 1week and 1month after phacoemulsification using EDI-OCT. 10 eyes of 10 patients were treated prophylactically with topical ketorolac 5mg/ml and the other 10 eyes (10patients) were treated with topical bromfenac 9mg/ml. Measurements were performed at the fovea and at 750, 1500 and 2250 μm from the fovea, in the horizontal and vertical scans. The RT and CT at 1 week and 1 month after phacoemulsification were compared to the respective values in the preoperative period(PP). RT and CT changes were compared between bromfenac-treated eyes and ketorolac-treated eyes.

Results : Mean-subfoveal CT(SFCT) measured at PP,1week and 1month were 202,0±55,0μm; 267,8±78,7μm and 239,4±51,2μm,respectively. Mean central RT at PP,1 week and 1 month were 242,6±23,1μm; 262,8±32,3μm and 262,5±64,1μm,respectively. There was a statistically significant increase in SFCT at 1week(p<0,001) and 1month(p=0,008).Mean CT in horizontal scans(HS) increased to 219,9±63,0μm(p=0,002) at 1week,and to 218,8±58,5μm(p=0,001)at 1month.In vertical scans (VS), CT increased to 237,9±66,0μm(p<0,001) at 1 week, and to 226,1±62,8μm(p<0,001)at 1 month. Mean RT in VS increased slightly to 316,0±19,9μm(p=0,024) at 1 week and 312,1±22,9μm(p=0,023) at 1 month after surgery. Mean RT in HS increased slightly to 316,6±19,6μm(p=0,026) at 1 week after surgery. There were not statistical significative differences in CT and RT changes between ketorolac and bromfenac groups (p>0,05).

Conclusions : Uncomplicated phacoemulsification can induce nonpathologic increases in choroidal and retinal thickness, even with prophylatic anti-inflammatory treatment, probably due to the post-operatory inflammatory insult. These subclinical post-operative changes in RT and CT appear to be similiar in both ketorolac and bromfenac prophylactic anti-inflammatory treatments. The macular OCT is useful in monitoring the subclinical macular retinal and choroidal changes in thickness that can occur after uneventful cataract surgery.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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