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Adriana Di Polo; Mechanisms of retinal ganglion cell dendrite stability and regeneration. Invest. Ophthalmol. Vis. Sci. 201657(12):.
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© 2017 Association for Research in Vision and Ophthalmology.
Presentation Description :
It is increasingly being recognized that injury to retinal ganglion cell (RGC) axons triggers rapid pathological changes in dendrites. Despite the fact that dendritic and synaptic defects are likely to have devastating consequences on neuronal function and survival, the mechanisms that regulate RGC dendrite degeneration in glaucoma are vastly unknown. In this presentation, novel insights into molecular pathways that regulate RGC dendrite stability and regeneration will be highlighted. A better understanding of the processes that regulate dendritic stability or loss will be critical for the development of targeted therapies to maintain or enhance RGC connectivity and function in optic neuropathies.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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