September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Previous intravitreal therapy is associated with increased risk of posterior capsule rupture during cataract surgery.
Author Affiliations & Notes
  • Alex C Day
    UCL Institute of Ophthalmology, London, United Kingdom
  • Aaron Lee
    University of Washington, Seattle, Washington, United States
  • Catherine A Egan
    Moorfields Eye Hospital, London, United Kingdom
  • Clare Bailey
    Bristol Eye Hospital, Bristol, United Kingdom
  • Robert Johnston
    Gloucestershire Hospitals NHS Foundation Trust, , Cheltenham, United Kingdom
  • Marie Tsaloumas
    University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
  • Alastair K Denniston
    University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
    Birmingham & Midland Eye Centre, Birmingham, United Kingdom
  • Adnan Tufail
    Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships   Alex Day, None; Aaron Lee, None; Catherine Egan, None; Clare Bailey, None; Robert Johnston, Alimiera Science (F), Bayer pharmaceuticals (F), IMS (F), Novartis pharmaceuticals & Alcon (F); Marie Tsaloumas, ALIMERIA (R), ALLERGAN (R), Bayer (F), NOVARTIS (R); Alastair Denniston, None; Adnan Tufail, None
  • Footnotes
    Support  NIHR
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Alex C Day, Aaron Lee, Catherine A Egan, Clare Bailey, Robert Johnston, Marie Tsaloumas, Alastair K Denniston, Adnan Tufail; Previous intravitreal therapy is associated with increased risk of posterior capsule rupture during cataract surgery.. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate if previous intravitreal therapy is a predictor of posterior capsule rupture (PCR) during cataract surgery.

Methods : Anonymized data were extracted for eyes undergoing cataract surgery from 20 hospitals using the same EMR for cases performed between 2004 and 2014. Variables included as possible risk indicators for PCR were age, sex, number of previous intravitreal injections, indication for intravitreal therapy, grade of healthcare professional administering intravitreal therapy and cataract surgeon training grade.

Results : Data were available on 65,836 cataract operations, of which 1,935 had undergone previous intravitreal therapy (2.99%). In univariate regression analyses, increasing patient age, junior cataract surgeon grade and number of previous intravitreal injections were significant predictors of PCR. Considering number of previous intravitreal injections as a continuous variable, the OR for PCR per intravitreal injection was 1.034 (p=0.010) after adjusting for increasing age and cataract surgeon grade. Similar analysis considering intravitreal injections as a categorical variable, showed 10 or more previous injections were associated with a 2.146 times higher likelihood of PCR (p=0.002) after again adjusting for age and surgeon grade.

Conclusions : Previous intravitreal therapy is associated with a higher likelihood of posterior capsule rupture during cataract surgery. This study provides data to help inform surgeons and patients about the risk of complications when undergoing cataract surgery after multiple prior intravitreal injections. Further investigation is required to determine the aetiology behind the increased PCR risk.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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