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Shizuka Koh, Yukiko Nagahara, Yoshihiro Oshita, Takashi Nagano, Hidetoshi Mano, Hitoshi Watanabe, Kohji Nishida; Diquafosol ophthalmic solution increases pre- and post-lens tear film during contact lens wear in rabbit eyes. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1473.
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© ARVO (1962-2015); The Authors (2016-present)
Decreased tear volume is a change related to contact lens (CL) wear. Prolonged increases in pre-lens tear meniscus height after instillation of 3% diquafosol ophthalmic solution during CL wear was previously reported. However, the post-lens tear film dynamics remain unknown. The aim of the present study was to investigate the behaviors of pre-lens tear film (PLTF) and post-lens tear film (PoLTF) after instillation of diquafosol by using an experimental rabbit model of eyes with CL.
Cross-sectional anterior segment optical coherence tomographic images of the inferior mid-peripheral cornea were obtained at baseline, and 5, 15, 30, 60, 90, and 120 min after instillation of 3% diquafosol ophthalmic solution in 10 Japanese rabbits wearing CLs. From the obtained images, the area of the PLTF and PoLTF were calculated. Both 0.1% sodium hyaluronate ophthalmic solution and artificial tear solution were used as controls.
Fluid accumulation in PoLTF was observed 5 min after instillation of diquafosol and reached a peak at 15 min, followed by gradual reduction up to 120 min. PoLTF after instillation of diquafosol significantly increased from the baseline at 15 and 30 min (both P < 0.01). No fluid accumulation in PoLTF was observed after instillation of sodium hyaluronate and artificial tear. The increase in PoLTF up to 60 min after instillation of diquafosol was significantly higher (P < 0.01) than that after instillation of sodium hyaluronate and artificial tear. PLTF also significantly increased from its baseline value 30 min after diquafosol instillation (P < 0.05). The increase in PLTF after diquafosol instillation was significantly higher (P < 0.01) at 15 and 30 min than after instillation of sodium hyaluronate and artificial tear.
Instillation of 3% diquafosol ophthalmic solution increased PLTF and PoLTF in the rabbit eyes with CLs. Therefore, it has potential as treatment option for CL-related dry eyes.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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