September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Influence of disease duration on choroidal neovascularization (CNV) microstructures in eyes with age-related macular degeneration (AMD) as assessed by optical coherence tomography angiography (OCTA)
Author Affiliations & Notes
  • Reinhard Told
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Andreas Pollreisz
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Florian Sulzbacher
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Stefan Sacu
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships   Reinhard Told, None; Andreas Pollreisz, None; Florian Sulzbacher, None; Stefan Sacu, None; Ursula Schmidt-Erfurth, Alcon Lab. Inc. (C), Bayer Healthcare (C), Boehringer (C), Novartis (C)
  • Footnotes
    Support   none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1617. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Reinhard Told, Andreas Pollreisz, Florian Sulzbacher, Stefan Sacu, Ursula Schmidt-Erfurth; Influence of disease duration on choroidal neovascularization (CNV) microstructures in eyes with age-related macular degeneration (AMD) as assessed by optical coherence tomography angiography (OCTA). Invest. Ophthalmol. Vis. Sci. 2016;57(12):1617.

      Download citation file:


      © 2017 Association for Research in Vision and Ophthalmology.

      ×
  • Supplements
Abstract

Purpose : To compare AMD-CNV microstructures in untreated and treated eyes based on OCTA with disease duration.

Methods : A total of 85 eyes of 85 consecutive patients with untreated or treated neovascular AMD (nAMD) (20 treatment naïve eyes, 65 eyes with previous anti-VEGF treatment) were examined using the AngioVue OCTA system (Optovue, Fremont, CA) and evaluated based on CNV morphology by two independent graders.
CNV was classified according to the following patterns: dense net (DN); vascular loop (VL); mixed (DN+VL). Further, CNV lesions were subcategorized based on vessel characteristics: branches with tiny capillaries; branches with single rare large vessels; anastomosis/loops; peripheral arcade. Based on nAMD onset, patients were grouped into 4 cohorts: Group A (no history of previous nAMD); Group B (diagnosis within last 2 years); Group C (2-4 years); Group D (4-9 years).

Results : In 10 (50%) treatment naïve and 40 (61%) previously treated eyes, CNV lesions were identified on OCTA. Groups A, B, C and D consisted of 20, 25, 25 and 15 eyes, respectively. The mean number of injections in groups B, C and D was 4.8±3.44, 14.6±8.83 and 23.8±7.5 (mean ± SD), respectively.
Regarding main CNV types, DN could be observed in 21.1% of eyes in group A; 16% (C); 13.3% (D) and 8.3% (B); VL was most frequently present in group D (60%), followed by C (48%), A (21.1%) and B (12.5%). Mixed patterns were found in 16.7% of eyes in group B; 12% in C; 10.5% in A and 6.7% in D. The largest number of eyes with absent CNV lesions on OCTA was found in group B (62.5%), followed by A (47.4%), D (33.3%) and C (24%).
Grading of subcategories revealed that group A contained the most tiny capillary branches (31.6%), while the majority of branches with single rare large vessels was found in groups C (66.7%) and D (60%). Anastomosis/loops were most often observed in groups D (53%) and C (48%). In 21.1% of eyes in group A, 13.3% in D and 8% in C peripheral arcades were identified, while none were observed in eyes of group B.

Conclusions : In eyes with newly diagnosed nAMD, OCTA revealed specific microstructural CNV characteristics such as DN and branches with tiny capillaries. With disease duration and injection frequency vascular loop patterns and the presence of anastomosis/loops within the CNV lesion increased.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×