September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
New imaging possibilities in the assessment of branch retinal artery occlusion:
A comparison between OCT angiography and fluorescein angiography
Author Affiliations & Notes
  • Max Loidl
    Ophthalmology, University of Ulm, Neu-Ulm, Germany
  • Christian Enders
    Ophthalmology, University of Ulm, Neu-Ulm, Germany
  • Gerhard K Lang
    Ophthalmology, University of Ulm, Neu-Ulm, Germany
  • Gabriele Elisabeth Lang
    Ophthalmology, University of Ulm, Neu-Ulm, Germany
  • Footnotes
    Commercial Relationships   Max Loidl, Carl Zeiss Meditec, Inc. (F); Christian Enders, Carl Zeiss Meditec, Inc. (F); Gerhard Lang, Carl Zeiss Meditec, Inc. (F); Gabriele Lang, Alcon Pharma GmbH (F), Bayer Vital GmbH (F), Boehringer Ingelheim Pharma GmbH (F), Boehringer Ingelheim Pharma GmbH (R), Carl Zeiss Meditec, Inc. (F), Novartis GmbH (F), Novartis GmbH (R)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1642. doi:
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    • Get Citation

      Max Loidl, Christian Enders, Gerhard K Lang, Gabriele Elisabeth Lang; New imaging possibilities in the assessment of branch retinal artery occlusion:
      A comparison between OCT angiography and fluorescein angiography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1642.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare novel optical coherence tomography angiography (OCTA), which allows at present qualitative image analysis, with fluorescein angiography (FA) findings in patients affected by embolic branch retinal artery occlusion (BRAO).

Methods : In this prospective study subjects with acute and chronic BRAO were analyzed. The age of the patients ranged from 50 to 90 years. We included two female and 9 male patients. All sujects underwent a complete ophthalmological examination including fundus photography, FA and OCTA (AngioPlex, Carl Zeiss Meditec, Inc.). Qualitative OCTA analysis was performed on retinal images segmented into the superficial and deep retinal capillary plexus. In contrast to FA, OCTA gives a three-dimensional information on retinal capillary nonperfusion.

Results : Eleven consecutive subjects were enrolled in this study. We examined six acute BRAO and five patients with chronic BRAO. Images of both methods are highly corresponding in acute and chronic BRAO concerning the area of flow interruption in OCTA and nonperfusion in FA. Zones of decreased vascular perfusion were more pronounced in the deep retinal capillary plexus in comparison to the superficial retinal capillary plexus in 9/11 eyes. In acute BRAO the quality of the images can be reduced by retinal edema, however it was sufficient for analysis. In chronic BRAO perfusion defects are better visible in OCTA images in comparison to FA.

Conclusions : OCTA images generated from superficial and deep retinal capillary plexus allow detection of non-perfused areas in patients with acute and chronic BRAO equal to FA. In comparison to the superficial the deep capillary plexus seems to be more severely affected in the majority of patients. Advantages of OCTA are that this technique is non-invasive and allows for three-dimensional microvascular visualization. These findings suggest that OCTA has the capability to replace FA in the assessment of BRAO in most patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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