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Lu Lin, Jing Lu, Guiying Mai, Mei Li, Di Cao, Xiao Wang, Yan Luo; Peripheral fundus in normal eyes by ultra-widefield fluorescein angiography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1643.
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© ARVO (1962-2015); The Authors (2016-present)
To characterize the appearance of peripheral fundus of normal eyes via ultra-widefield fluorescein angiography (UWFA).
A total of 123 eyes of 78 subjects with best corrected visual acuity > 1.0, without any visible pathologic changes in the retina underwent Heidelberg UWFA and Heidelberg 55-degree FA. According to peripheral angiographic findings, eyes were allocated into three groups: group 1 without mottled fluorescent band and retinal vascular leakage; group 2 with mottled fluorescent band and without retinal vascular leakage; group 3 with vascular leakage, regardless of the existence of mottled fluorescent band. Ciliary body thickness (CBT) was measured by ultrasound biomicroscopy and compared in three groups.
In the ora serrata region, a mottled fluorescent band was detected in 54 eyes (43.9%). In retinal periphery just posterior to the ora serrata, a granular band of background fluorescence appeared in all eyes (100%) and vascular leakage was observed in 40 eyes (32.5%). No sex and age differences existed between three groups. CBT values of group 1 (CBT1: 0.240+0.019mm, CBT2: 0.375+0.051mm) and group 2 (CBT1: 0.251+0.030mm, CBT2: 0.410+0.050mm) showed no statistical difference (p = 0.531 for CBT1, p = 0.150 for CBT2); while CBT values of group 3 (CBT1: 0.337+0.046mm, CBT2: 0.623+0.107mm) were significantly different from those of the other two groups (p = 0.000 for both CBT1 and CBT2), indicating potential inflammation in eyes of vascular leakage.
Standard peripheral fundus has a granular band of background fluorescence, without any mottled fluorescent band or vascular leakage. The mottled fluorescent band may be a kind of developmental variation, while the vascular leakage may be an early sign of uveitis.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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