September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
OCT-ANGIOGRAPHY FEATURES OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS
Author Affiliations & Notes
  • Andrea Mazzaferro
    Ophtalmology departement, Policlinico Universitario G. Martino, Messina, Italy
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Eleonora Corbelli
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Maria Vittoria Cicinelli
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Adriano Carnevali
    IRCCS Ospedale San Raffaele, Milano, Italy
    University of Magna Graecia , Catanzaro, Italy
  • Maurizio Battaglia Parodi
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Ilaria Zucchiatti
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Lucia Benatti
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Lea Querques
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Francesco Bandello
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Giuseppe Querques
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Footnotes
    Commercial Relationships   Andrea Mazzaferro, None; Eleonora Corbelli, None; Maria Vittoria Cicinelli, None; Adriano Carnevali, None; Maurizio Battaglia Parodi, None; Ilaria Zucchiatti, None; Lucia Benatti, None; Lea Querques, None; Francesco Bandello, Alcon (C), Alimera science (C), Allergan (C), Bausch & Lomb (C), Bayer (C), Farmila Thea (C), Genentec (C), Hofmann La Roche (C), Novagali Pharma (C), Novartis (C), Sanofi aventis (C), Thrombogenics (C); Giuseppe Querques, Alimera Science (C), Allergan (C), Bausch and Lomb (C), Bayer Schering Pharma (C), Heidelberg (C), Novartis (C), Zeiss (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1647. doi:
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      Andrea Mazzaferro, Eleonora Corbelli, Maria Vittoria Cicinelli, Adriano Carnevali, Maurizio Battaglia Parodi, Ilaria Zucchiatti, Lucia Benatti, Lea Querques, Francesco Bandello, Giuseppe Querques; OCT-ANGIOGRAPHY FEATURES OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1647.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Choroidal neovascularization (CNV) is one of the main complications of an angioid streaks (AS). Aim of the study is to describe the Optical Coherence Tomography Angiography (OCT-A) features of CNV secondary to AS.

Methods : We retrospectively analyzed 9 patients presenting between September 2015 and November 2015 at the Medical Retina Service of the University Vita-Salute San Raffaele in Milan . Each patient underwent multimodal retinal imaging: multicolor imaging, fluorescein angiography (FA), spectral-domain (SD)-OCT, OCT-A (AngioPlex™, CIRRUS HD-OCT models 5000, Carl Zeiss Meditec, Inc., Dublin, USA). OCT-A features of CNV were analyzed and two types of denomination were proposed: “interlacing” and “tangled” vascular network. Automatic segmentation provided by the machine software was manually adjusted.

Results : Thirteen eyes of 9 patients (5 males / 4 females) with AS and CNV (mean age 60.8 ± 8.2 years) were included for analysis. In all eyes we found agreement between OCTA, FA and SD-OCT images in detecting CNV. CNV appeared on OCT-A as a hyper-intense vascular network of variable size. Seven eyes (53.8 %) showed an “interlacing” network and 6 eyes (46.2 %) a “tangled” network. The interlacing appearance was more often associated with signs of activity on multimodal imaging.

Conclusions : OCT-A is a very useful non-invasive tool to detect and characterize CNV associated with AS.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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