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Aoi Kominami, Shuichiro Hirahara, Miho Nozaki, Tsutomu Yasukawa, Yuichiro Ogura; Evaluation of choroidal circulatory disturbance with Ultra-Wide field Indocyanine Green Angiography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1649.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the choroidal circulatory disturbance with ultra-widefield indocyanine green angiography (ICGA).
All patients who underwent simultaneous ultra-widefield fluorescein angiography (FA) and ICGA for diagnostic purpose and disease treatment monitoring by using Optos® California scanning laser ophthalmoscope (Optos PLC., Dunfermline, Scotland, UK) at Nagoya City University from May to October in 2015 were reviewed. These patients were also evaluated by HRA2 (Heidelberg Engineering Retinal Angiograph 2, Heidelberg Engineering, Germany) FA/ICGA on same day. The area of choroidal vessels in polypoidal choroidal vasculopathy (PCV) was also calculated. ICGA images were binarized, and the area of choroidal vessels within the range drawn by connecting the ampullas of vortex veins and the area were measured. Then the density of choroidal vessel within the area was calculated. All the procedure during calculation was performed by using Image J software.
Ultra-widefield ICGA was performed on 222 eyes of 159 patients. Mean age was 66.5 ± 18.5 years (range, 22-89 years). The most common ocular disease included diabetic retinopathy (73 eyes), PCV (39 eyes), age-related macular degeneration (38 eyes), uveitis (19 eyes), retinal vein occlusion (16 eyes), central serous chorioretinopathy (CSC) (8 eyes). Choroidal vessels were clearly visualized towards periphery in ultra-widefield ICGA images in all cases. The image quality of posterior pole captured by Optos® California was comparable to these obtained by HRA2 with 30 degrees of views. In Vogt-Koyanagi-Harada disease (8 eyes), multiple hypofluorescent patches extended from posterior pole to peripheral area. Choroidal vessels in CSC were markedly dilated. The density of choroidal vessels in 8 eyes of 8 patients with PCV and 11 eyes of 11 age-matched patients without retinal diseases were calculated. The density of choroidal vessels was significantly high in PCV group compared with control group at total area (P<0.05, Mann–Whitney U test) (PCV group: total area 36.92±0.70%, control group: total area 34.26±0.77%).
In this series of 222 eyes, ultra-widefield ICGA was clinically useful and showed all areas of vasculature in a single capture. There was a trend of dilation of choroidal vessels in PCV group compared with control.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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