September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Qualitative and quantitative assessment of retinal vascular impairment due to Epiretinal membrane: an OCT-Angiography analysis
Author Affiliations & Notes
  • Fiore Tito
    Department of Biochemical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy
  • Marco Lupidi
    Department of Biochemical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy
    Centre Ophtalmologique De L'Odeon, Paris, France
  • Florence Coscas
    Centre Ophtalmologique De L'Odeon, Paris, France
    Centre Hospitalier Intercommunal de Créteil, Creteil, France
  • Carlo Cagini
    Department of Biochemical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy
  • Gabriel J Coscas
    Centre Ophtalmologique De L'Odeon, Paris, France
    Centre Hospitalier Intercommunal de Créteil, Creteil, France
  • Footnotes
    Commercial Relationships   Fiore Tito, None; Marco Lupidi, None; Florence Coscas, None; Carlo Cagini, None; Gabriel Coscas, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1650. doi:
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      Fiore Tito, Marco Lupidi, Florence Coscas, Carlo Cagini, Gabriel J Coscas; Qualitative and quantitative assessment of retinal vascular impairment due to Epiretinal membrane: an OCT-Angiography analysis. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1650.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To perform a qualitative and quantitative analysis of the foveal microvasculature changes due to epiretinal membranes using optical coherence tomography angiography (OCT-A).

Methods : Retrospective case series of 20 eyes of 20 patients affected by ERM (11 females, mean age 69.2 ± 4.6 years) and 30 eyes of 30 age-matched controls, evaluated by Spectralis OCT-A (Heidelberg Engineering, Heidelberg, Germany). The Full-spectrum amplitude-decorrelation angiography (FSADA) generated high-resolution optical coherence tomography angiograms of the superficial and deep capillary plexa. Morphological changes such as focal vessel’s dilations, vessel’s interruptions or perifoveal arcade disruptions were qualitatively analyzed and recorded on OCT-A images. Moreover a fully automated micro-structural analysis of the FAZ, foveal vessel’s density and non-perfused areas was performed (in a 1-mm-radius area). Quantitative values of ERM patients were then compared with those of healthy subjects.

Results : In the superficial capillary plexus, focal vessel’s dilations, vessel’s interruptions or perifoveal arcade disruptions were present in all ERM eyes. Conversely, in the deep capillary plexus, these abnormalities were detected in a lower number of cases. Capillary density values were significantly lower in nearly all layers of ERM patients compared with healthy subjects. There was high (p< 0.05) inter-observer agreement both for morphological and quantitative OCT-A imaging analysis.

Conclusions : OCT-A is a useful technology for detecting vascular abnormalities due to ERM both in the superficial and deep capillary plexa. The fully automated quantitative retinal vascular analysis may offer an objective method for monitoring disease progression and potentially the functional response to the surgical treatment.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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