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Shinichiro Ishikawa, Yukiyasu Yoshinaga, Daisuke Nakamura, Tatsuo Okada, Tatsuro Ishibashi, Hiroshi Enaida; Development and evaluation of the novel fundus oximetry. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1655.
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© 2017 Association for Research in Vision and Ophthalmology.
We developed a novel fundus oximetry and evaluate of optical density ration (ODR) about the retinal major vessels and the microcirculation areas under normal and in hypoxic conditions.
In this system ODR measured by the original algorithm and software. The software makes major vessel ODR mapping images by calculated ODR with convergence index filter (MV mode). Also, the software makes whole fundus ODR mapping images by calculated arterial red blood cells' ODR with spatial affected effect (WF mode). Systemic hypoxia was induced in healthy volunteers by held their breath under pulse oximeter monitored condition.
At MV mode, ORDs were measured as 0.73±0.024 for arterioles and 1.12±0.096 for venules in normal subjects (mean ± SD, N = 4, P =0.029). At WM mode, ODR mapping images showed wider ODR area as became lower SpO2.
The novel fundus oximetry is first whole fundus' ODR measurable system in non-invasive condition.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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