September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Correlations between retinal vessel calibers and neurodegeneration in patients with no or mild diabetic retinopathy in the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR).
Author Affiliations & Notes
  • Jakob Grauslund
    Ophthalmology, Odense University Hospital, Odense, Denmark, Denmark
  • Ulrik Frydkjaer-Olsen
    Ophthalmology, Odense University Hospital, Odense, Denmark, Denmark
  • Rasmus Soegaard Hansen
    Ophthalmology, Odense University Hospital, Odense, Denmark, Denmark
  • Rafael Simo
    Vall d'Hebron, Barcelona, Spain
  • Jose G Cunha-Vaz
    Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
  • Tunde Peto
    Ophthalmology, Odense University Hospital, Odense, Denmark, Denmark
  • Footnotes
    Commercial Relationships   Jakob Grauslund, None; Ulrik Frydkjaer-Olsen, None; Rasmus Hansen, None; Rafael Simo, None; Jose Cunha-Vaz, None; Tunde Peto, None
  • Footnotes
    Support  European Union's Seventh Framework Programme for research, technological development and demonstration (grant agreement 278040)
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1663. doi:
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      Jakob Grauslund, Ulrik Frydkjaer-Olsen, Rasmus Soegaard Hansen, Rafael Simo, Jose G Cunha-Vaz, Tunde Peto; Correlations between retinal vessel calibers and neurodegeneration in patients with no or mild diabetic retinopathy in the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR).. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1663.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : To investigate the correlations between retinal vessel calibers and neurodegeneration in patients with type 2 diabetes and no or mild diabetic retinopathy (DR).

Methods : We included baseline data of 440 patients with type 2 diabetes from a 2-year prospective, interventional, clinical, multicenter trial (EUROCONDOR, NCT01726075). For the study eye, 7-field 30-35° color fundus photos were used to grade for DR, and patients with ETDRS-levels 10-35 were included in the trial. Disc-centered images were analyzed for retinal vessel diameters with semi-automatic software (IVAN). Calibers were summarized into central retinal artery and vein equivalent (CRAE and CRVE). Spectral Domain OCT and multifocal electroretinography (mf-ERG) was used to measure structural and functional neurodegenerative changes, respectively.

Results : Median age and duration of diabetes was 64 and 10.3 years, and 66.1% were men. ETDRS levels were 10 (42.3%), 20 (37.5%) and 35 (30.2%). Median CRAE and CRVE was 146.7 µm and 215.3 µm. CRAE did not differ according to ETRDS-level (p=0.12), but wider CRVE were found in patients with higher levels of DR (214.5 µm, 213.2 µm and 216.6 µm for ETDRS-levels 10, 20 and 35, respectively, p=0.04). In univariate analyses, CRAE correlated with ganglion cell layer (GCL) thickness (r=0.25, p<0.01) and mean mf-ERG amplitude of ring 1-6 (r=0.10, p=0.03). CRVE correlated with GCL thickness (r=0.19, p<0.01) and retinal nerve fiber layer (RNFL) thickness (r=0.11, p=0.02). Positive correlations between CRAE and mf-ERG amplitudes (ring 2, 3, 5, 6 and mean, p<0.01-0.03) were found in patients with ETDRS-level 20, but not in level 10 or 35. CRVE correlated inversely with mf-ERG implicit time in patients with ETDRS-level 10 (ring 3-6 and mean, p=0.02-0.04), but positively in patients with ETDRS-level 20 (ring 4, 6 and mean, p=0.01-0.02). In an overall multivariable linear regression model, CRAE was associated with GCL thickness (coefficient 0.19 per µm, p<0.01), and CRVE was correlated with RNFL thickness (coefficient 0.13 per µm, p<0.01).

Conclusions : Retinal vessel calibers were independently associated with structural and functional neurodegeneration. Different correlations were found in patients with no and minimal DR. This suggests a complex neurovascular interaction in the early stages of DR.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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