September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Clinical statistics for recurrence of Vogt-Koyanagi-Harada disease
Author Affiliations & Notes
  • Naka Shiratori
    Nippon Medical School, Tokyo, Japan
  • Tomoyuki Kunishige
    Nippon Medical School, Tokyo, Japan
  • Junko Hori
    Nippon Medical School, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Naka Shiratori, None; Tomoyuki Kunishige, None; Junko Hori, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1870. doi:
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      Naka Shiratori, Tomoyuki Kunishige, Junko Hori; Clinical statistics for recurrence of Vogt-Koyanagi-Harada disease. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1870.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the clinical statistics for recurrence of Vogt-Koyanagi-Harada disease patients, including recurrence rate, site of recurrence and treatments before and after recurrence, and treatment outcomes.

Methods : A retrospective review study involved 29 Vogt-Koyanagi-Harada disease patients who visited Nippon Medical School Hospital from January 2008 to December 2014.

Results : The ratio of male to female was 13:16. The age averaged 42.0 ± 15.2 years in male, 41.9 ± 14.8 years in female. The observation period averaged 30 ± 25 months. The subjects included 22 new onset cases, 1 recurrent case, 3 chronic cases and 3 follow-up cases after treatment at other hospitals at the time of initial visit. All new onset cases received pulse corticosteroid therapy followed by oral prednisolone. Recurrent episodes occurred in 8 (28%) cases. Among them, five cases recurred while tapering oral prednisolone, whereas 3 cases recurred after the end of oral prednisolone. Treatments after recurrence were different by type of recurrence; 5 cases of recurrent anterior uveitis had been cured by topical ocular corticosteroid therapy, and 3 cases of recurrent posterior uveitis with exudative retinal detachment had need to be treated with systemic corticosteroid and/or systemic cyclosporine. Choroidal neovascularization developed in 2 (7%) cases, and intra vitreous injection of ranibizumab was effective.

Conclusions : The recurrence rate of Vogt-Koyanagi-Harada disease in Nippon Medical School Hospital was 28%. Although the recurrent anterior uveitis was cured by topical ocular corticosteroid, systemic corticosteroid and/or systemic cyclosporine therapy were necessary to cure the recurrent exudative retinal detachment.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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