September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Choroidal Thickness in patients with Vogt-Koyanagi-Harada disease using enhanced depth imaging optical coherence tomography (EDI-OCT)
Author Affiliations & Notes
  • Cristobal A Couto
    Uveitis , University Of Buenos Aires , Buenos Aires, Argentina
  • Erika Hurtado
    Uveitis , University Of Buenos Aires , Buenos Aires, Argentina
  • Bernardo Ariel Schlaen
    Uveitis , University Of Buenos Aires , Buenos Aires, Argentina
  • Fernanda Pascuet
    Uveitis , University Of Buenos Aires , Buenos Aires, Argentina
  • Marina Khoury
    Uveitis , University Of Buenos Aires , Buenos Aires, Argentina
  • Footnotes
    Commercial Relationships   Cristobal Couto, None; Erika Hurtado, None; Bernardo Schlaen, None; Fernanda Pascuet, None; Marina Khoury, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1874. doi:
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      Cristobal A Couto, Erika Hurtado, Bernardo Ariel Schlaen, Fernanda Pascuet, Marina Khoury; Choroidal Thickness in patients with Vogt-Koyanagi-Harada disease using enhanced depth imaging optical coherence tomography (EDI-OCT). Invest. Ophthalmol. Vis. Sci. 2016;57(12):1874.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : Purpose: To assess the choroidal thickness (CT) and the correlation with disease duration using enhanced depth imaging optical coherence tomography (EDI-OCT) in patients with Vogt-Koyanagi-Harada (VKH) disease under treatment according to the different stages of the disease.

Methods : Methods: VKH patients irrespectively of disease stage were prospectively enrolled in a study at the Uveitis Clinic of the University of Buenos Aires from July 2014 through July 2015. Patients underwent a comprehensive ophthalmic examination and choroidal imaging using horizontal EDI-OCT across the fovea to measure the CT. Subfoveal CT greater than 335 microns were classified as choroidal thickenning and lower than 287 microns as choroidal thinning.

Results : Results: 42 VKH patients, 33 female/9 male, mean age 37 years (r =17 – 73) were recruited. 32 patients received a single evaluation and 10 patients received 2 or more exams. CT was assessed in 109 eyes with 56 measurements using OCT EDI performed in average 60 months since diagnosis. Mean CT in 109 measurements was 271 micrones (r = 98 – 648). The CT measurements at the foveal centre presented a negative correlation with disease duration (r= -0.43; p<0.0001). Out of 78 eyes in convalescent stage, 20 had choroidal thickenning and 46 choroidal thinning. Out of 21 eyes in recurrent stage, 6 had choroidal thickenning and 13 choroidal thinning, while out of 10 eyes in the acute stage, 8 had choroidal thickenning and none had choroidal thinning, (p<0.01)


Conclusions : Conclusion: Progressive choroidal thinning related to disease duration was observed at the macula of treated VKH patients, being more frequent in the convalescent stage compared to the choroidal thickenning in the acute stage.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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