September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Association of fluorescein anterior corneal mosaic and corneal K-structures by in vivo laser confocal microscopy in patients with keratoconus
Author Affiliations & Notes
  • Akira Kobayashi
    Ophthalmology & Visual Science, Kanazawa Univ Sch of Medicine, Kanazawa, Ishikawa, Japan
  • Hideaki Yokogawa
    Ophthalmology & Visual Science, Kanazawa Univ Sch of Medicine, Kanazawa, Ishikawa, Japan
  • Toshinori Masaki
    Ophthalmology & Visual Science, Kanazawa Univ Sch of Medicine, Kanazawa, Ishikawa, Japan
  • Natsuko Mori
    Ophthalmology & Visual Science, Kanazawa Univ Sch of Medicine, Kanazawa, Ishikawa, Japan
  • Kazuhisa Sugiyama
    Ophthalmology & Visual Science, Kanazawa Univ Sch of Medicine, Kanazawa, Ishikawa, Japan
  • Footnotes
    Commercial Relationships   Akira Kobayashi, None; Hideaki Yokogawa, None; Toshinori Masaki, None; Natsuko Mori, None; Kazuhisa Sugiyama, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 1926. doi:
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      Akira Kobayashi, Hideaki Yokogawa, Toshinori Masaki, Natsuko Mori, Kazuhisa Sugiyama; Association of fluorescein anterior corneal mosaic and corneal K-structures by in vivo laser confocal microscopy in patients with keratoconus. Invest. Ophthalmol. Vis. Sci. 2016;57(12):1926.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To report the in vivo laser confocal microscopy findings of a cornea with keratoconus with special attention to the abnormality of Bowman’s layer and sub-Bowman’s fibrous structures (K-structures).

Methods : Twelve kertoconic eyes in 6 keratoconus patients (2 male, 4female, mean 39.7 years old) were included in this study. Slit lamp biomicroscopic photo with or without fluorescein staining were taken. The existence of anterior corneal mosaic (ACM) after eyelid rubbing under fluorescein staining were documented. In vivo laser confocal microscopic examinations were performed for all patients in both central cone and pheripheral cornea to examine the existence of K-structures.

Results : ACM was observed in 5 eyes (41.7%) in cone area and 12 eyes (100%) in peripheral cornea. Also, K-structures was observed in 5 eyes (41.7%) that had ACM in cone area and 12 eyes (100%) in peripheral cornea. The existence and non-existence of the K-structure was completely matched (100%) with the existence of ACM in both central cone and pheripheral cornea.

Conclusions : The existence of ACM and K-structures in both central cone and pheripheral cornea showed perfect accord in keratoconus patients, indicating a strong association of ACM and K-structure in patients with keratoconus. Further study using larger groups of keratoconic patients is required to fully understand the significance of ACM/K-structurse in keratoconic eyes and their association with Bowman’s layer.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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