September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Macular Thickness Changes on Spectral Domain Optical Coherence Tomography in Pediatric Population with Sickle Cell Disease at Yale
Author Affiliations & Notes
  • Syed Amal Hussnain
    Ophthalmology and Visual Science , Yale University School of Medicine, New Haven , Connecticut, United States
  • Patrick Coady
    Ophthalmology and Visual Science , Yale University School of Medicine, New Haven , Connecticut, United States
  • Judith Carbonella
    Pediatric Hematology, Yale University School of Medicine, New Haven, Connecticut, United States
  • Farzana Pashankar
    Pediatric Hematology, Yale University School of Medicine, New Haven, Connecticut, United States
  • Ron A Adelman
    Ophthalmology and Visual Science , Yale University School of Medicine, New Haven , Connecticut, United States
  • Kathleen Stoessel
    Ophthalmology and Visual Science , Yale University School of Medicine, New Haven , Connecticut, United States
  • Footnotes
    Commercial Relationships   Syed Hussnain, None; Patrick Coady, None; Judith Carbonella, None; Farzana Pashankar, None; Ron Adelman, None; Kathleen Stoessel, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2059. doi:
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      Syed Amal Hussnain, Patrick Coady, Judith Carbonella, Farzana Pashankar, Ron A Adelman, Kathleen Stoessel; Macular Thickness Changes on Spectral Domain Optical Coherence Tomography in Pediatric Population with Sickle Cell Disease at Yale. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2059.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : To correlate spectral domain optical coherence tomogoraphy (SDOCT) macular thickness parameters with prevalence and severity of sickle retinopathy in pediatric patients with sickle cell disease (SCD) at Yale.

Methods : Retrospective medical record review of 141 consecutive pediatric SCD patients who underwent retinal evaluation at Yale over a 10-year period was performed, of which 25 patients (50 eyes) had SDOCT imaging of the macula. In these patients, we correlated macular thickness values with the presence and severity of sickle retinopathy, type of SCD, fetal hemoglobin levels (HgF), and lowest hemoglobin (Hgb) level to date.

Results : Of the 50 eyes (34SS, 10SC, 2S0Arab, 2Sbetaplus thal, 2Sbetathal) analyzed, 15 had proliferative (PSR), 20 had non-proliferative (NPSR), and 15 had no sickle cell retinopathy (NSR). Mean age of NSR, NPSR, and PSR patients was 17.1 ± 2.1, 17.9 ± 5.8, and 19.3 ± 2.9 years, respectively. There was no statistically significant difference in average macular thickness (275.7 ± 3.2 μm vs. 285.1 ± 7.2 μm, p=0.19) and macular volume (9.9 ± 0.1 mm3 vs. 10.3 ± 0.3 mm3, p=0.19) between NPSR and PSR, respectively. Age and HgF did not correlate with any of the 9 Early Treatment Diabetic Retinopathy Study (EDTRS) macular thickness subfields. Lowest Hgb values showed a significant correlation with inner (r=0.38, p<0.007) and outer (r=0.37, p<0.009) temporal, inner superior (r= 0.30, p<0.03), and inner nasal (r= 0.32, p<0.02) ETDRS subfields on macular SDOCT.

Conclusions : Our results suggest that temporal thinning observed on macular SDOCT patients in SCD may be directly related to the level of anemia in this population. This may indicate the need for obtaining macular OCTs to detect subclinical macular thinning in SCD patients with episodes of severe anemia.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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