September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Comparison of aqueous concentrations of angiogenic and inflammatory cytokines based on optical coherence tomography patterns of diabetic macular edema
Author Affiliations & Notes
  • Seung Jun Lee
    Ophthalmology, Kangwon National University, Chuncheon, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Seung Jun Lee, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2068. doi:
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      Seung Jun Lee; Comparison of aqueous concentrations of angiogenic and inflammatory cytokines based on optical coherence tomography patterns of diabetic macular edema. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2068.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : The purpose was to compare aqueous inflammatory and angiogenic cytokine levels in diabetic macular edema (DME).

Methods : Aqueous samples were obtained from 50 eyes with DME and 12 normal eyes (control group). DME was classified according to the morphologic pattern based on optical coherence tomography: Diffuse retinal thickening (DRT; n=19), cystoid macular edema (CME; n=17), or serous retinal detachment (SRD; n=14). Aqueous samples were collected just before intravitreal injection and at the beginning of cataract surgery in the control group. Interleukin (IL)-6, IL-8, interferon-induced protein (IP)-10, monocyte chemotactic protein (MCP)-1, platelet-derived growth factor (PDGF)-AA, and vascular endothelial growth factor (VEGF) levels were measured by multiplex bead assay.

Results : The IL-6, IL-8, IP-10, and PDGF-AA levels differed significantly among the three groups of DME (P=0.014, P=0.038, P=0.021, and P=0.041, respectively). However, there were no differences between groups in aqueous concentration levels of MCP-1 and VEGF (P=0.205 and P=0.062, respectively). IL-6 (P=0.026) and IL-8 (P=0.023) correlated positively with central foveal thickness (CFT) in the CME group. None of the cytokine levels correlated significantly with CFT in any of the DRT and SRD groups.

Conclusions : Aqueous concentrations of cytokines varied according to the morphologic pattern of DME, which might explain the variable response to treatments such as intravitreal bevacizumab or triamcinolone injection.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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