Purchase this article with an account.
Yuichi Toriyama, Takao Hirano, Motoharu Tokimitsu, Dai Chiba, Toshiyuki Kyomoto, Toshinori Murata; Changes in aqueous concentrations of various cytokines after intravitreal ranibizumab for diabetic macular edema.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2072.
Download citation file:
© 2017 Association for Research in Vision and Ophthalmology.
To investigate the changes in aqueous cytokine levels after intravitreal injection of ranibizumab(IVR) for diabetic macular edema (DME).
Aqueous humor samples were collected before and at 4 weeks after IVR from 18 eyes with DME, and concentrations of 27 cytokines were measured using a multiplex bead immunoassay.
The aqueous VEGF concentrations decreased below the lowest detectable limit in 16 of the 18 eyes at 4 weeks after IVR (P < 0.001; mean baseline 374.35 pg/ml). IL-10 and IL-12 concentrations also showed a significant decrease (IL-10, 4.55→0.32 pg/ml, P < 0.001; IL-12, 37.79→0.81 pg/ml, P < 0.001). Only IP-10 concentrations showed a significant increase after IVR (717.5→1165.3 pg/ml, P < 0.005). VEGF, IL-10 and IL-12 concentrations were correlated with the severity of diabetic retinopathy. There was a significant correlation between the increase in the IP-10 concentrations after IVR and improvement of retinal thickness ( R = 0.59, P < 0.05).
IVR influence on the aqueous concentrations of IL-10, IL-12 and IP-10 as well as VEGF.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
This PDF is available to Subscribers Only