September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Changes in aqueous concentrations of various cytokines after intravitreal ranibizumab for diabetic macular edema.
Author Affiliations & Notes
  • Yuichi Toriyama
    Department of Ophthalmology, Shinshu university, Matsumoto, Japan
  • Takao Hirano
    Department of Ophthalmology, Shinshu university, Matsumoto, Japan
  • Motoharu Tokimitsu
    Department of Ophthalmology, Shinshu university, Matsumoto, Japan
  • Dai Chiba
    Department of Ophthalmology, Shinshu university, Matsumoto, Japan
  • Toshiyuki Kyomoto
    Department of Ophthalmology, Shinshu university, Matsumoto, Japan
  • Toshinori Murata
    Department of Ophthalmology, Shinshu university, Matsumoto, Japan
  • Footnotes
    Commercial Relationships   Yuichi Toriyama, Novartis (F); Takao Hirano, Novartis (F); Motoharu Tokimitsu, Novartis (F); Dai Chiba, Novartis (F); Toshiyuki Kyomoto, Novartis (F); Toshinori Murata, Novartis (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2072. doi:
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      Yuichi Toriyama, Takao Hirano, Motoharu Tokimitsu, Dai Chiba, Toshiyuki Kyomoto, Toshinori Murata; Changes in aqueous concentrations of various cytokines after intravitreal ranibizumab for diabetic macular edema.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2072.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : To investigate the changes in aqueous cytokine levels after intravitreal injection of ranibizumab(IVR) for diabetic macular edema (DME).

Methods : Aqueous humor samples were collected before and at 4 weeks after IVR from 18 eyes with DME, and concentrations of 27 cytokines were measured using a multiplex bead immunoassay.

Results : The aqueous VEGF concentrations decreased below the lowest detectable limit in 16 of the 18 eyes at 4 weeks after IVR (P < 0.001; mean baseline 374.35 pg/ml). IL-10 and IL-12 concentrations also showed a significant decrease (IL-10, 4.55→0.32 pg/ml, P < 0.001; IL-12, 37.79→0.81 pg/ml, P < 0.001). Only IP-10 concentrations showed a significant increase after IVR (717.5→1165.3 pg/ml, P < 0.005). VEGF, IL-10 and IL-12 concentrations were correlated with the severity of diabetic retinopathy. There was a significant correlation between the increase in the IP-10 concentrations after IVR and improvement of retinal thickness ( R = 0.59, P < 0.05).

Conclusions : IVR influence on the aqueous concentrations of IL-10, IL-12 and IP-10 as well as VEGF.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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