September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Impact of central cyst on functional and anatomical outcomes in diabetic macular edema treated by ranibizumab
Author Affiliations & Notes
  • Pierre-Antoine REY
    Ophtalmology, Avicenne Hospital, Paris, France
  • Franck Fajnkuchen
    Ophtalmology, Avicenne Hospital, Paris, France
  • Linda Hrarat
    Ophtalmology, Avicenne Hospital, Paris, France
  • sylvia nghiem-buffet
    Ophtalmology, Avicenne Hospital, Paris, France
  • Valérie Sarda
    Ophtalmology, Avicenne Hospital, Paris, France
  • Audrey Giocanti
    Ophtalmology, Avicenne Hospital, Paris, France
  • Gilles Chaines
    Ophtalmology, Avicenne Hospital, Paris, France
  • Footnotes
    Commercial Relationships   Pierre-Antoine REY, None; Franck Fajnkuchen, None; Linda Hrarat, None; sylvia nghiem-buffet, None; Valérie Sarda, None; Audrey Giocanti, None; Gilles Chaines, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2087. doi:
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      Pierre-Antoine REY, Franck Fajnkuchen, Linda Hrarat, sylvia nghiem-buffet, Valérie Sarda, Audrey Giocanti, Gilles Chaines; Impact of central cyst on functional and anatomical outcomes in diabetic macular edema treated by ranibizumab. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2087.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The purpose of our study is to evaluate the functional and anatomical efficiency of ranibizumab intravitreal injection in patient with diabetic macular edema (DME) with or without central cyst.

Methods : This is a retrospective single-center observational study from March 2011 to November 2015.
Patients with diabetic macular edema requiring ranibizumab injection were included. A first group (G1) included patients with a central cyst and a control group (G2) included patients without central cyst.
A cyst is defined in optical coherence tomography (OCT) as central if it has a central bulge above the tangential line at the interface vitreomacular plan.
The main outcomes measured were the mean change of best-corrected visual acuity (BCVA) from baseline to 3rd month, 6th mont and 12th month. Secondary outcomes were the number of intravitreal injection and central retinal thickness (CRT) mean change.

Results : Seventy eight eyes (60 patients) were included: 20 eyes in G1 ans 58 in G2.
The initial average of BCVA was 43,5 letters for G1 and 50,5 for G2. At baseline, CRT was 550,9μm in G1 and 512μm in G2.
At 3 months, in G1, the average change in BCVA was +13.75 letters, the average variation of the CRT was -193μm. In G2, the average change in BCVA was +10,27 letters, the average variation of the CRT was -142,7μm. There were 2.85 intravitreal injection in G1 and 2.71 in G2.
At 6 months, in G1, the average change in BCVA was +18,25 letters, the average variation of the CRT was -194μm. In G2, the average change in BCVA was +12,2 letters, the average variation of the CRT was -144,3μm. There were 4 intravitreal injection in G1 and 3,86 in G2.
At 12 months, in G1, the average change in BCVA was +13,45 letters, the average variation of the CRT was -183,3μm. In G2, the average change in BCVA was +11,53 letters, the average variation of the CRT was -158,1μm. There were 5,65 intravitreal injection in G1 and 5,22 in G2.

Conclusions : In this study we do not find significant difference in the gain of BCVA between patients with or without an initial central cyst.
A central cyst in diabetic macular edema do not seem to be a poor prognostic factor on functional and anatomical efficiency of ranibizumab intravitreal injection.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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