September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Evaluation of En-face OCT Images in Diabetic Macular Edema with Anti-VEGF Treatment
Author Affiliations & Notes
  • Shintaro Horie
    Ophthalmology, Tokyo Medical and Dental University, Tokyo, Japan
  • Mitsunao Ide
    Ophthalmology, Tokyo Medical and Dental University, Tokyo, Japan
  • Kei Morohoshi
    Ophthalmology, Tokyo Medical and Dental University, Tokyo, Japan
  • Kyoko Ohno-Matsui
    Ophthalmology, Tokyo Medical and Dental University, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Shintaro Horie, None; Mitsunao Ide, None; Kei Morohoshi, None; Kyoko Ohno-Matsui, None
  • Footnotes
    Support  JSPS KAKENHI Grant number 26861438
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2110. doi:
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    • Get Citation

      Shintaro Horie, Mitsunao Ide, Kei Morohoshi, Kyoko Ohno-Matsui; Evaluation of En-face OCT Images in Diabetic Macular Edema with Anti-VEGF Treatment. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2110.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : In diabetic macular edema (DME), en-face OCT presents two-dimensional distribution of microcysts, which intuitively indicates severity of the disease. In this study, utility of area measured by en-face OCT was examined comparing with the other factors in sectional OCT.

Methods : 17 eyes of 14 DME patients in our outpatient clinic (Tokyo Medical and Dental University Hospital), who were given anti-VEGF therapy (either Ranibizumab or Aflibercept) and en-face OCT examination (RTVueXR Avanti®) from March 2015 to November 2015, were included. Data obtained from clinical records and OCT images were retrospectively examined. The area of DME was measured by en-face OCT (3mm square). The central or maximum retinal thickness was measured by sectional swept-source OCT (Topcon Atlantis®). Correlation analysis was performed within the areas of macular edema, central retinal thickness and maximum retinal thickness.

Results : The area of DME measured by en-face OCT was significantly correlated with central retinal thickness by sectional OCT (p<0.0001). When comparing before and after administrations of the anti VEGF drugs, the alteration of area and that of maximum retinal thickness were significantly related (p=0.011). In this study, the comparison between the Ranibizumab treated and the Aflibercept treated group showed no significant differences in those factors.

Conclusions : En-face OCT is useful for clinical management of DME not only it give us intuitive two-dimensional pathology but also it is related to other conventional factors in sectional OCT. Utilizing en-face OCT in the assessment of therapeutic effects is also hopeful.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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