September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Optical Coherence tomographic Angiography features in neovascularization secondary to angioid streaks
Author Affiliations & Notes
  • thibaut Chapron
    Paris Descartes University, Paris, France
    ophthalmology, Centre Inter Communal Créteil, Creteil, France
  • Gerard Mimoun
    ophthalmology, Centre Inter Communal Créteil, Creteil, France
  • Mayer Srour
    ophthalmology, Centre Inter Communal Créteil, Creteil, France
  • Alexandra Miere
    ophthalmology, Centre Inter Communal Créteil, Creteil, France
  • Ala Elameen
    ophthalmology, Centre Inter Communal Créteil, Creteil, France
  • Oudy Semoun
    ophthalmology, Centre Inter Communal Créteil, Creteil, France
  • Eric H Souied
    ophthalmology, Centre Inter Communal Créteil, Creteil, France
    Paris Est University Créteil Val de Marne, Créteil, France
  • Footnotes
    Commercial Relationships   thibaut Chapron, None; Gerard Mimoun, None; Mayer Srour, None; Alexandra Miere, None; Ala Elameen, None; Oudy Semoun, None; Eric Souied, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2148. doi:
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      thibaut Chapron, Gerard Mimoun, Mayer Srour, Alexandra Miere, Ala Elameen, Oudy Semoun, Eric H Souied; Optical Coherence tomographic Angiography features in neovascularization secondary to angioid streaks. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2148.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : Optical coherence tomography angiography (OCT-A) is a new non-invasive technique allowing us imaging retinal microvasculature. We performed a prospective observational study in order to detect the presence of neovascularization (CNV) secondary to angioid streaks and to describe their morphological features on OCT-A.

Methods : We analyzed consecutive patients affected with CNV secondary to angioid streaks. All patients underwent a complete ophthalmological examination including best-corrected visual acuity (BCVA), fluorescein angiography (FA), indocyanine green angiography (ICG) and spectral domain optical coherent tomography (SD-OCT; Heidelberg Engineering, Heidelberg; Germany). Presence and activity of CNV was determined on FA, ICG and SD-OCT imaging by two observers. Two others observers, blind from the activity in standard imaging, evaluated OCT-A images to identify the presence of CNV and to describe the features of the lesion. OCT-A was performed using the RTVue XR Avanti (Optovue Inc). We proposed four types of CNV features on OCT-A: “sea fan” characterized by a dense vascular network, “interlacing vessels” characterized by a tortuous network with many hyperdense vascular ramifications without significant dead space, “loop” characterized by a rarified curved and tortuous vascular network, and “dead tree” characterized by linear vascular network with dead spaces between.

Results : 32 eyes of 18 consecutive patients with neovascularization secondary to angoid streaks were prospectively included. Median age was 60 years-old (range 40-71).
In FA, ICG and SD-OCT, CNV were classified as active lesions in 13/32 eyes at the time of imaging and 12/32 eyes were not injected in the last 6 months. OCT-A showed the presence of CNV in 28/32 (87,5%) eyes. Finally, 4 CNV lesions were classified as “seafan”, 6 as “interlacing vessels”, 3 as “loop”, 4 as “dead tree”, and 11 CNV showed associated forms.

Conclusions : OCT-A has the ability to detect 87,5% CNV secondary to angioid streaks. Classic exudative signs are rare in SD-OCT. OCT-A does not appear yet to be sufficient alone to determine if CNV is active or not but could be useful in association with SD-OCT in order to show CNV modifications during follow-up.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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