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thibaut Chapron, Gerard Mimoun, Mayer Srour, Alexandra Miere, Ala Elameen, Oudy Semoun, Eric H Souied; Optical Coherence tomographic Angiography features in neovascularization secondary to angioid streaks. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2148.
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© ARVO (1962-2015); The Authors (2016-present)
Optical coherence tomography angiography (OCT-A) is a new non-invasive technique allowing us imaging retinal microvasculature. We performed a prospective observational study in order to detect the presence of neovascularization (CNV) secondary to angioid streaks and to describe their morphological features on OCT-A.
We analyzed consecutive patients affected with CNV secondary to angioid streaks. All patients underwent a complete ophthalmological examination including best-corrected visual acuity (BCVA), fluorescein angiography (FA), indocyanine green angiography (ICG) and spectral domain optical coherent tomography (SD-OCT; Heidelberg Engineering, Heidelberg; Germany). Presence and activity of CNV was determined on FA, ICG and SD-OCT imaging by two observers. Two others observers, blind from the activity in standard imaging, evaluated OCT-A images to identify the presence of CNV and to describe the features of the lesion. OCT-A was performed using the RTVue XR Avanti (Optovue Inc). We proposed four types of CNV features on OCT-A: “sea fan” characterized by a dense vascular network, “interlacing vessels” characterized by a tortuous network with many hyperdense vascular ramifications without significant dead space, “loop” characterized by a rarified curved and tortuous vascular network, and “dead tree” characterized by linear vascular network with dead spaces between.
32 eyes of 18 consecutive patients with neovascularization secondary to angoid streaks were prospectively included. Median age was 60 years-old (range 40-71).In FA, ICG and SD-OCT, CNV were classified as active lesions in 13/32 eyes at the time of imaging and 12/32 eyes were not injected in the last 6 months. OCT-A showed the presence of CNV in 28/32 (87,5%) eyes. Finally, 4 CNV lesions were classified as “seafan”, 6 as “interlacing vessels”, 3 as “loop”, 4 as “dead tree”, and 11 CNV showed associated forms.
OCT-A has the ability to detect 87,5% CNV secondary to angioid streaks. Classic exudative signs are rare in SD-OCT. OCT-A does not appear yet to be sufficient alone to determine if CNV is active or not but could be useful in association with SD-OCT in order to show CNV modifications during follow-up.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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