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Ioannis K Petropoulos, Pietro Roberti, Michel A Matter, Philippe M Desmangles; Usefulness of Optical Coherence Tomography Angiography in Myopic Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2150.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the ability of optical coherence tomography angiography (OCT-angiography) to detect choroidal neovascularization secondary to pathologic myopia in patients with contraindication for fluorescein angiography.
Three women (55, 85, and 93 years old, respectively) with pathologic myopia and suspected choroidal neovascularization in one eye participated in this study. Vision decrease and metamorphopsia were the symptoms in all cases. Fluorescein angiography was contraindicated due to allergy in two cases and due to advanced age in one case. The patients were evaluated by OCT, en-face OCT, and OCT-angiography (XR-Avanti; Optovue). Split spectrum amplitude decorrelation angiography algorithm was used to detect the blood flow within the tissue. Scan protocols covering a 3 mm x 3 mm area and a 8 mm x 8 mm area were used.
Imaging with OCT and en-face OCT showed, in all cases, a hyperreflective lesion at the level of the retinal pigment epithelium (RPE) and/or the outer retina with minimal or no fluid, making diagnosis of choroidal neovascularization doubtful. In contrast, OCT-angiography clearly showed, in all cases, a distinct neovascular network at the level of the choriocapillaris adjacent to the RPE. This led to efficient regression of the choroidal neovascularization by intravitreal anti-VEGF therapy with visual acuity improvement in all cases.
OCT-angiography is a useful noninvasive imaging technique to detect choroidal neovascularization secondary to pathologic myopia in cases with contraindication for fluorescein angiography. This technique provides detailed images of distinct vascular networks in various depths, enabling accurate diagnosis of choroidal neovascularization and good follow-up after treatment.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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