September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Intrasession repeatability of swept-source optical coherence tomography derived choroidal thickness measurements in neovascular age related macular degeneration
Author Affiliations & Notes
  • Daren Hanumunthadu
    NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Tomas Ilginis
    NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Marie Restori
    NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Mandeep S Sagoo
    NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
    Barts Health NHS Trust, London, United Kingdom
  • Adnan Tufail
    NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Kamaljit S Balaggan
    NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
    Wolverhampton and Midland Counties Eye Infirmary, Wolverhampton, United Kingdom
  • Praveen J Patel
    NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Footnotes
    Commercial Relationships   Daren Hanumunthadu, SalutarisMD (R); Tomas Ilginis, SalutarisMD (F); Marie Restori, SalutarisMD (F); Mandeep Sagoo, SalutarisMD (F); Adnan Tufail, Allergan (C), Bayer (C), Genetech (C), Heidelberg Engineering (C), Novartis (F), Novartis (E), Roche (C), SalutarisMD (R); Kamaljit Balaggan, SalutarisMD (C), SalutarisMD (R); Praveen Patel, Bayer (C), HeidelbergInc (F), Novartis (C), SalutarisMD (R), ThrombogenicsNV (F), Thrombogenics NV (C), TopconInc (F)
  • Footnotes
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Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2169. doi:
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      Daren Hanumunthadu, Tomas Ilginis, Marie Restori, Mandeep S Sagoo, Adnan Tufail, Kamaljit S Balaggan, Praveen J Patel; Intrasession repeatability of swept-source optical coherence tomography derived choroidal thickness measurements in neovascular age related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2169.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Changes in choroidal thickness may be associated with macular conditions including age related choroidopathy and pachychoroid. Several studies have reported variation in OCT-derived choroidal thickness measurements in patients with neovascular age related macular degeneration (nAMD) being treated with anti-angiogenic agents. Although this may be a promising structural marker of disease activity, an understanding of its repeatability is required in order to define true clinical change rather than measurement variability alone. The aim of this work was to describe the repeatability of choroidal thickness measurements in nAMD using a commercially available swept-source OCT (SS-OCT) device (DRI-OCT-1, TopCon Inc).

Methods : 39 eyes of 39 patients with nAMD were included in the study. Each patient underwent a 12 x 9mm raster scan using the DRI-OCT-1. The scans were repeated three times in the same imaging session by a clinical trial certified technician. Submacular choroidal thickness measurements were calculated using the on-board segmentation algorithm for each of the nine ETDRS (Early Treatment Diabetic Retinopathy Study) subfields. Coefficients of repeatability were calculated for each of these subfields according to methods described by Bland and Altman.

Results : Mean (±SD) age of each patient was 73.9 (±7.2) years. There were 24 male and 15 female subjects. This consisted of 21 right and 18 left eyes. The intrasession coefficient of repeatability (CR) of choroidal thickness of the central macular subfield (A1) was 57.2μm with a mean retinal thickness of 181mm (±15.8μm). The CR of the other macular subfields ranged from 38.5μm to 60.3μm.

Conclusions : This study suggests that variation of more than 57μm in choroidal thickness is necessary to suggest clinical variation due to disease activity rather than measurement alone. This may be useful in the interpretation of studies investigating variation in SS-OCT derived choroidal thickness measurements in nAMD during treatment with anti-angiogenic agents. Further analysis is needed to define SS-OCT derived choroidal thickness measurements as an outcome variable in clinical trials in nAMD.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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