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Machiko Kimura, Ichiro Maruko, Moeko Kawai, Hideki Koizumi, Yukinori Sugano, Takeshi Muraki, Hisaya Arakawa, Tetsuju Sekiryu, Tomohiro Iida; Lesion size measurement using optical coherence tomography in polypoidal choroidal vasculopathy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2170.
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© 2017 Association for Research in Vision and Ophthalmology.
Photodynamic therapy (PDT) is one of the treatment of polypoidal choroidal vasculopathy (PCV) because of polypoidal regression. PDT needs to measure the greatest linear dimension (GLD) after fluorescein angiography and/or indocyanine green angiography (IA). In the current study, we measured the pathological lesion size (LS) and GLD using optical coherence tomography (OCT) for non-invasive approach.
Fifteen eyes of 15 patients (11 men, 4 women, and average 73 year-old) with PCV was examined. All eyes were examined by IA and OCT (DRI-OCT, Topcon) in Tokyo Women’s Medical University or Fukushima Medical University. GLD and LS were measured in IA images (IA-GLD and IA-LS). The measurement of GLD using IA was referred to the report by Otani et al (AJO 2007). GLD and LS based in OCT (OCT-GLD and OCT-LS) were measured by the irregular area of retinal pigment epithelium (RPE) in en-face OCT images using the open source image analysis software (ImageJ). Reliability of all results were evaluated by the interclass correlation coefficient (ICC).
Mean LS was 3.54 ±1.66 mm2 in IA-LS and 4.40 ±2.47 mm2 in OCT-LS, respectively. Mean GLD was 2825 ±675 μm in IA-GLD and 2984±971 μm in OCT-GLD, respectively. ICC between IA and OCT were 0.61 in LS and 0.83 in GLD (both p<0.01).
GLD was correlated more than LS. OCT can measure the GLD for PDT, however it is not enough to measure the RPE irregularity in OCT for the evaluation of the exact exudative area.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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