September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Normative Values of Retinal Oxygen Saturation in Rhesus Monkeys: The Beijing
Intracranial and Intraocular Pressure (iCOP) Study
Author Affiliations & Notes
  • Jing Li
    Ophthalmology, Beijing Tongren Hospital, Beijing, China
  • Diya Yang
    Ophthalmology, Beijing Tongren Hospital, Beijing, China
  • Yiquan Yang
    Ophthalmology, Beijing Tongren Hospital, Beijing, China
  • Ningli Wang
    Ophthalmology, Beijing Tongren Hospital, Beijing, China
  • Footnotes
    Commercial Relationships   Jing Li, None; Diya Yang, None; Yiquan Yang, None; Ningli Wang, None
  • Footnotes
    Support  National Natural Science Foundation of China 81300767
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2205. doi:
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      Jing Li, Diya Yang, Yiquan Yang, Ningli Wang; Normative Values of Retinal Oxygen Saturation in Rhesus Monkeys: The Beijing
      Intracranial and Intraocular Pressure (iCOP) Study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2205.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : To study the normal values of the retinal oxygen saturation in Rhesus Monkeys and to evaluated repeatability and reproducibility of retinal oxygen saturation measurements.

Methods : Eighteen adult Rhesus macaque monkeys were included in this experimental study. An Oxymap T1 retinal oximeter (Oxymap , Reykjavik, Iceland) was used to perform oximetry on all subjects. Global arterial (SaO2) and venous oxygen saturation (SvO2), arteriovenous difference in SO2 were measured. In the first examination, each eye was imaged three times. At the following two examinations, each eye was imaged once. Intraclass correlation coefficient (ICC) was determined.

Results : Average SaO2 and SvO2 were 89.48 ± 2.64% and 54.85 ± 2.18%, respectively. The global A-V difference was 34.63 ± 1.91%. The highest A-V difference in SO2 and lowest saturations were found in the inferotemporal quadrant. Intra-session and inter-visit repeatability were both high. For all oxygen saturation parameters, the
ICC values of the intra-session repeatability ranged between 0.92 and 0.96. The lowest values were in the infero-temporal quadrant. As found previously, a relatively high ICC value for inter-visit repeatability also was found for all oxygen satuation measurements, ranging between 0.86 and 0.94, with the lowest values in the infero-nasal quadrant.

Conclusions : Our study is the first to describe retinal SO2 in healthy Rhesus monkeys. In normal monkey eyes, the reproducibility and repeatability of retinal oximetry oxygen saturation measurements were high in the retinal arterioles and venules. In conclusion, our results support retinal oximetry as suitable for assessing changes in follow-up examinations for ocular diseases in experimental monkey studies.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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