September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Diagnosis cytomegalovirus anterior uveitis/endothelitis in immunocompetent patients.
Author Affiliations & Notes
  • Laure E Caspers
    Ophthalmology, CHU St Pierre, Brussels, Brussels, Belgium
    Université Libre de Bruxelles, Brussels, Belgium
  • Joelle Antoun
    Univ of Brussels-St Pierre Hosp, Brussels, Belgium
  • Jolanda de Groot-Mijnes
    University Medical Center Utrecht, Utrecht, Netherlands
  • Elie Motulsky
    Ophthalmology, CHU St Pierre, Brussels, Brussels, Belgium
    Ophthalmology, CHU Brugmann, Brussels, Brussels, Belgium
  • N.H.ten Dam-van Loon
    University Medical Center Utrecht, Utrecht, Netherlands
  • François Willermain
    Univ of Brussels-St Pierre Hosp, Brussels, Belgium
    Ophthalmology, CHU Brugmann, Brussels, Brussels, Belgium
  • Lia Judice Relvas
    Univ of Brussels-St Pierre Hosp, Brussels, Belgium
    Ophthalmology, CHU Brugmann, Brussels, Brussels, Belgium
  • Footnotes
    Commercial Relationships   Laure Caspers, None; Joelle Antoun, None; Jolanda de Groot-Mijnes, None; Elie Motulsky, None; N.H.ten Dam-van Loon, None; François Willermain, None; Lia Judice Relvas, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2338. doi:
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      Laure E Caspers, Joelle Antoun, Jolanda de Groot-Mijnes, Elie Motulsky, N.H.ten Dam-van Loon, François Willermain, Lia Judice Relvas; Diagnosis cytomegalovirus anterior uveitis/endothelitis in immunocompetent patients.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2338.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose :

Purpose: To evaluate the diagnostic methods and clinical signs leading the diagnosis of CMV anterior uveitis (AU) and/or endothelitis from 2 uveitis tertiary referral center in Brussels (Belgium) and in Utrecht (Nederland).

Methods : A retrospective study of patients with a clinical diagnosis of CMV AU and endothelitis with positive polymerase chain reaction (PCR) and or Goldmann-Witmer coefficient (GWc) positive.

Results : Results: We report a series of 19 patients presenting clinical characteristics of CMV AU and /or endothelitis including ring-shaped (coin-shaped) KPs, Posner-Shlossman syndrome and Fuchs heterochromic iridocyclitis with a positive PCR and/or GWc for CMV. There was 13/19 (68.4 %) males, 2 Asian (10.5%). At diagnosis, the mean was 37.0 years [14-62], all (100%) were unilateral and 16/18 (88.9%) had elevated intraocular pressure (IOP) > 25 mm Hg (mean elevated IOP: 41.6 mm Hg). PCR was tested in all the 19 patients while GWc was only tested in 8 patients. PCR was positive for CMV in 14/19 patients (73.7 %) and GWc was positive for CMV in 7/8 patients (87.5%), both PCR and GW were positive for CMV in 2 patients. Aqueous tap was repeated in 8 patients (2 times in 5 cases, 3 times in 2 cases) to be able to confirm the clinical diagnosis of CMV anterior uveitis/endothelitis.

Conclusions : Conclusion: the biological confirmation by PCR of clinical diagnosis of CMV AU/ endothelitis remains difficult and can be improved by repeated aqueous taps and GWc measurement.
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This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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