September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Blood thyroid hormone levels and corneal tomographical, topographical and biomechanical properties
Author Affiliations & Notes
  • Zsuzsa Flaskó
    Department of Ophthalmology, Kenézy Hospital, Debrecen, Hungary
    Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar, Germany
  • Elena Zemova
    Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar, Germany
  • Timo Eppig
    Experimental Ophthalmology, Saarland University, Homburg/Saar, Germany
  • László Módis
    Department of Ophthalmology, Debrecen Medical University Center, Debrecen, Hungary
  • Achim Langenbucher
    Experimental Ophthalmology, Saarland University, Homburg/Saar, Germany
  • Zisis Gatzioufas
    Moorfields Eye Hospital, London, United Kingdom
  • Nóra Szentmáry
    Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar, Germany
    Department of Ophthalmology, Semmelweis University, Budapest, Hungary
  • Berthold Seitz
    Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar, Germany
  • Footnotes
    Commercial Relationships   Zsuzsa Flaskó, None; Elena Zemova, None; Timo Eppig, None; László Módis, None; Achim Langenbucher , None; Zisis Gatzioufas, None; Nóra Szentmáry, None; Berthold Seitz, None
  • Footnotes
    Support  HARVO (Hungarian Association for Research in Vision and Ophthalmology) Travel Grant
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2396. doi:
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      Zsuzsa Flaskó, Elena Zemova, Timo Eppig, László Módis, Achim Langenbucher, Zisis Gatzioufas, Nóra Szentmáry, Berthold Seitz; Blood thyroid hormone levels and corneal tomographical, topographical and biomechanical properties. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2396.

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Abstract

Purpose : Hypothyroidism could be associated with keratoconus and may be one of its causing factors. Our aim was to determine the potential impact of blood thyroid hormone levels on corneal topography, tomography and biomechanics.

Methods : 757 eyes (376 left eyes, 500 males) were included in our study. Patients were classified as euthyroid (n=563) or hypothyroid (n=194) based on blood thyroid hormone status (TSH, FT3, FT4). We further subdivided hypothyroid patients in those with (n=122) and without (n=72) medication. Patients were examined using TMS-5 topographer (Tomey, Tennenlohe, Germany)(keratoconus index: KCI; keratoconus severity index: KSI; keratoconus prediction index: KPI), Pentacam HR tomographer (Oculus Optikgeräte GmbH, Wetzlar, Germany)(keratoconus index: KI; central keratoconus index: CKI) and Ocular Response Analyzer (ORA, Reichert Ophthalmic Instruments, Buffalo, NY) (corneal resistance factor: CFR; corneal hysteresis: CH; keratoconus match index: KMI).

Results : Using Mann-Whitney U test, KCI, KSI, KPI of TMS-5 and KI, CKI of Pentacam were significantly lower in hypothyroid patients with medication compared to euthyoids or hypothyroid patients without medication (p<0.001 for all). In addition, KMI, CH and CRF of ORA were significantly greater in hypothyreosis patients with medication compared to euthyroids or hypothyroid patients without medication (p<0.001 for all). Using a generalised linear model, KMI depended on blood FT3 level (p=0.029), however, other parameters of TMS-5, Pentacam or ORA were not affected significantly by blood TSH, FT3 or FT4 levels (p>0.136).

Conclusions : Blood TSH, FT3 and FT4 levels may affect keratoconus specific indices of corneal topography and tomography, and corneal biomechanical properties. Unlike in keratoconus, an abnormally increased KMI index of ORA may be indicative for reduced FT3 blood level and hypothyreosis.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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